CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Molecular and Cellular Biologist - investigate mechanisms involved in muscle wasting diseases. Our research group is using cellular, molecular, and bioinformatics approaches to better understand the pathways that mediate protein loss associated with muscle wasting diseases including cancer and heart failure. We are particularly interested in how noncoding regulatory RNAs, such microRNAs, regulate muscle atrophy. The long-term goal is to not only to better dissect the function and mechanisms by which genes regulates muscle wasting, but also translate this information to identify new drug targets to support the development of new therapeutic strategies. (Source: Lattes Curriculum)
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Cachexia is a multifactorial syndrome highly associated with specific tumor types, but the causes of the variation in the prevalence and severity of cachexia are still unknown. Although circulating plasma mediators (soluble cachectic factors) derived from the tumor have been implicated with the pathogenesis of the syndrome, these associations were generally based on the plasma concentrati…
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expressi…
The Brazil-USA collaboration provides an exciting opportunity to explore different molecular, cellular, and physiological aspects of muscle wasting. OSU has expertise in cancer cachexia, especially dissecting the mechanisms by which NF-kB regulates muscle differentiation using different in vitro and in vivo experimental models for functional studies, which can complement the UNESP experti…
(Only some records are available in English at this moment)
Lung cancer is the second most prevalent and deadly cancer, accounting for 18% of all cancer deaths in 2020. Among the histological types of lung cancer, non-small cell lung cancer is the most common (~85%), with the subtype lung adenocarcinoma (LUAD) standing out. This subtype originates from lung glandular cells and affects ~40% of patients. The treatment is established according to tum…
Cancer-associated cachexia is a syndrome characterized by involuntary weight loss, mainly due to loss of muscle mass. It is a multifactorial metabolic syndrome associated with specific tumor types, but the variation causes in the prevalence and severity of cachexia are still unknown. RNA sequencing (RNA-Seq) revolutionized transcriptomic studies and allowed a better understanding of the m…
Muscular diseases are changes in skeletal muscle tissue caused by various defective structural proteins, deregulated molecular pathways and other mechanisms. Several research groups study these muscular alterations in order to clarify all the processes responsible for this condition that modify the skeletal muscles and leads to a progressive lethal degeneration of this tissue. The complex…
Cachexia is a metabolic syndrome characterized by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support, most found in patients with advanced cancer. The cancer cachexia molecular pathways are not completely known, however, advances in genomic, transcriptomic and proteomic studies in cancer have helped in understanding the relationship o…
Cachexia is multifactorial metabolical syndrome that is very common in advanced malignant neoplasms. Its main characteristic is the significant loss of muscle mass (with concomitant loss of fat or not), which can not be reversed by nutritional support, leading to progressive dysfunctions. This condition has been vastly considered as a paraneoplastic syndrome, in which tumor derived factor…
(Only some records are available in English at this moment)
Pro-inflammatory cytokines such as Tumor Necrosis Factor alpha (TNF) has been implicated in the pathogenesis of skeletal muscle atrophy in cachexia, a metabolic syndrome commonly associated with many chronic systemic inflammatory diseases such as cancer and AIDS. Although the up-regulation of mRNA levels in response to TNF signaling has been studied extensively in the context of immune ac…
The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such as sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases can be accompanied by a complex metabolic syndrome characterized by muscle wasting, known as cachexia. The molecular pathways responsible for cachexia are not com…
Micro-RNAs (miRNAs, miR) are small noncoding RNAs regulators with size ranging from 17 to 25 nucleotides. Currently, more than 21,000 miRNAs from 193 species were recorded, and humans are known 2042. In the nucleus, the pri-miRNA is processed to pre-miRNA by the enzyme RNase III (Drosha), which requires the protein DGCR8 (DiGeorge Syndrome critical region gene 8). The DGCR8/Drosha form a …
| 1 / 1 | Ongoing research grants |
| 8 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 14 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 29 / 25 | All research grants and scholarships |
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