She holds a degree in Biomedicine from the University of Mogi das Cruzes (1977), a Master's degree (1981), a PhD (1985) and a Full Professorship (2000) in Microbiology and Immunology from the Federal University of São Paulo- EPM. She completed post-doctorate studies at the University of Tennessee, Memphis, USA (1988), The New York Hospital-Cornell Medical Center, New York, USA (1996-1997) and the University of Maryland School of Medicine, Baltimore, USA (1998; 2000-2010). She is currently an Associate Professor and Full Professor at UNIFESP, Head of the Department of Microbiology, Immunology and Parasitology at UNIFESP-EPM (2016-present), Coordinator of the Biomedical Sciences Building at UNIFESP (2021-present) and Research Advisor at the São Paulo Campus of UNIFESP (2022-present). Has experience in the area of Microbiology (Bacteriology), with emphasis on bacterial pathogenicity and epidemiology of diarrheagenic Escherichia coli. (Source: Lattes Curriculum) (Source: Lattes Curriculum)
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Enteroaggregative Escherichia coli (EAEC) is defined by its characteristic aggregative adherence (AA) pattern to HEp-2 cells. The AA phenotype is mediated by plasmid-encoded aggregative adhesion fimbriae (AAF) and regulated by the pAA plasmid-encoded transcriptional activator AggR. Strains containing the AggR regulon are referred to as typical EAEC, in contrast, atypical EAEC strains lack…
Escherichia coli coli (EAEC) are identified by their ability to produce the aggregative adherence (AA) pattern to cultured epithelial cells. EAEC prototype strains adhere to HEp-2 cells and to intestinal mucosa by virtue of AAF (aggregative adherence fimbriae), which are encoded on pAA plasmids; all AAF biogenesis genes are controlled by the regulator called AggR. However, atypical EAEC s…
EPEC can be categorized into two subgroups, typical (tEPEC) and atypical (aEPEC), based on the presence or absence of the EPEC adherence factor plasmid (pEAF), respectively. EPEC colonizes the proximal small intestine, where it adheres to epithelial cells forming microcolonies. Microcolony formation is one of the initial steps in biofilm development, but, very little is known regarding bi…
The term atypical enteropathogenic Escherichia coli (atypical EPEC) is used to define E. coli strains that not have the EAF plasmid and do not produce Shiga toxin. Like typical EPEC and enterohemorhagic E. coli (EHEC) strains, atypical EPEC produce the attaching and effacing (A/E) lesion encoded by the LEE pathogenicity island. Atypical EPEC strains may belong to serotypes of the classica…
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SummaryEnteropathogenic Escherichia coli (EPEC) is subdivided into typical and atypical, and have the typical eae gene and EAF plasmid, and have atypical eae gene, but do not carry the EAF plasmid. Atypical EPEC has been found to cause diarrhea in several countries, including Brazil, surpassing the typical EPEC. Samples of atypical EPEC may or may not belong to the classical EPEC serogrou…
| 1 / 1 | Ongoing grants |
| 16 / 5 | Completed research grants |
| 17 / 2 | Completed scholarships in Brazil |
| 4 / 0 | Completed scholarships abroad |
| 38 / 8 | All research grants and scholarships |
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