CV Lattes
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Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes. Pró-Reitoria Acadêmica (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Pharmacy from the Federal University of Santa Catarina (UFSC) (2000). PhD in Biology Sciences, University of São Paulo (ICB-USP) (2002-2007) with postdoctoral degree at the Experimental Oncology Unit - Discipline of Cell Biology, at Federal University of São Paulo (UNIFESP) (2008-2014). Currently, she is a professor and researcher at the Integrated Nucleus of Biotechnology at University of Mogi das Cruzes (UMC). Experience in the Research Area, with Biochemistry and Cell Biology, working mainly in the following subjects: cancer, peptides, compounds with antitumor activity, mechanism of action of drugs and mechanisms of cell death. (Source: Lattes Curriculum)
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Melanoma is formed from the malignant transformation of melanocytes. Despite the low incidence in the population, it is considered the most serious type of Skin Cancer, due to its high rate of metastases. Contrastingly, Breast Cancer is one of the most prevalent types of cancer in the world. Peptides derived from the DNA-binding domain (POU domain) of the transcription factor BRN2 have sh…
The transcription factor Brn-2 is expressed in melanocyte cell lines and superexpressed in melanoma. The increase in Brn-2 expression is related to tumor formation, tumor progression and development of metastases. The three major intracellular signaling pathways that are involved in melanoma formation, the MAPK / BRAF, Wnt / ²-catenin and PI3K / Akt, Brn-2 regulates the expression of Brn-…
The transcription factor Brn-2 (POU3F2 / N-Oct-3) is involved to the normal development of melanocytic lineage, however, when overexpressed it can reactivate signals to an abnormal growth as in melanoma. Moreover, several studies showed that Brn-2 expression is regulated by three major signaling pathways in melanoma, the Wnt/-catenin, MAPK/BRAF and PI3K /Akt pathways.Brn-2 can regulate th…
Melanoma is skin cancer that originates from mutations in melanocytes, cells present in the basal layer of the epidermis. Although it has a low incidence, this type of cancer has a high mortality rate due to its metastatic potential. Cell death is a fundamental process for the development and maintenance of cells. However, tumor cells may be resistant to this mechanism. The most studied t…
Melanocytes are located in the basal layer of the epidermis, hair follicles, uveal eye tract and cochlea. Melanocytes are cells that produce of melanin, protein responsible for color to the skin, eye color and hair. Melanoma is originated when melanocytes undergo malignant transformation. This tumor cell results from the accumulation of genetic mutations able of modifying the expression o…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 3 / 1 | Completed scholarships in Brazil |
| 7 / 5 | All research grants and scholarships |
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