Abstract
The aims of this study will be: (1) To determine basal differences in gene expression in pulp vs. periodontal ligament (PDL) cells in healthy and hypophosphatasia-diagnosed (HPP) subjects, focusing on genes associated with differentiation/mineralization and inorganic phosphate (Pi) metabolism; (2) To determine the effect that Pi treatment exerts on pulp vs. PDL cells, in vitro. To obtain…