Sandro José Conde

• Abstract

  The São Roque Federal Institute is improving its equipment repertoire with the recent acquisition of some key items for research in molecular biology area. Recently the EU Court of Auditors reported that the Federal Institutes of Higher Education are lagged with laboratory facilities. The Federal Institute of São Roque has a laboratory infrastructure in the area of molecular biology at th…

  Upgrade and maintenance of "Laboratório de Análises" of São Paulo Federal Institute - São Roque Campus., AP.RT.INST

• Abstract

  It is known that estrogen (E2) and hormonal status of the patient are important for the proliferation and treatment of breast cancer (CaM). About thyroid hormone (T3), although epidemiological studies are still contradictory in relation to its influence on breast cancer, laboratory studies demonstrate its ability to increase the proliferation of cells with CaM E2 receptor (ER) positive, i…

  PI3K pathway activation on gene expression regulated by triiodothyronine and estradiol in breast cancer cell lines, AP.R

• Abstract

  It is known that the patient's hormone status is important for proliferation and treatment of breast cancer (CaM). As for the thyroid hormone (T3), despite the contradictory epidemiological studies regarding its influence on breast cancer, laboratory studies have demonstrated its ability to increase proliferation of cells with CaM of E2 receptor (ER) positive. Although T3 exert many actio…

  Indirect gene expression activation by triiodothyronine in breast cancer cell lines, BP.IC

• Abstract

  Recently our group demonstrated FBLN1 and the CLDN6 genes have been stimulated by E2 and T3 in MCF-7 cells. Thus,our hypothesis is that thyroid hormone alters the expression of FBLN1 and CLDN6 without the need of translocation to the nucleus, by activation of phosphatidylinositol-3-kinase (PI3K) pathway. We intend to elucidate the pathway of action of E2 and T3 in the activation of these …

  Activation of the PI3K pathway in the expression of FBLN1 and CLDN6 by triiodothyronine and estradiol in a breast carcinoma cell line, BP.IC

• Abstract

  Vitamin D is a fat-soluble compound which exerts its biological effects by binding to the vitamin D receptor (VDR). The VDR gene shows polymorphisms in the population, which may present variations in the efficiency of vitamin D actions. Some recent studies have shown nutritional therapy increasing the efficiency of healing process, as occur in burned patients, decreasing the comorbidities…

  Influence of polymorphisms TaqI and BsmI of vitamin D receptor on recuperation of burned patients, BP.IC

(Only some records are available in English at this moment)