Tatiana Rosado Rosenstock

• Abstract

  Neuroprogression is one of several theories that have been proposed to explain the neuropathological features of Schizophrenia (SHZ). According to it, cellular changes, such as modifications in cell proliferation, neuronal migration and differentiation, as well as alterations in synapse formation are increased by sequential psychotic episodes and aggravated in the absence of medical inter…

  Age-related mitochondrial metabolism and its relationship with neurogenesis in an animal model of schizophrenia, AP.R SPRINT

• Abstract

  Most rare and common neurodegenerative disorders have no effective treatment or cure. One reason is the lack of reliable cell or animal models that consistently replicate the disease phenotypes. The outlook for new treatments has become more hopeful with the recognition that many of these diseases involve perturbations of a few key cellular pathways. Two major contributing pathways, which…

  Investigating cellular homeostatic mechanisms underlying rare and prevalent neurodegenerative diseases using human induced pluripotent stem cells, AP.R
• Implication of metabolic and epigenetic modifications for neuroprotection: relevance to translational research, AO.R

(Only some records are available in English at this moment)

• Abstract

  Among all hypotheses related to Schizophrenia (SZ), we can highlight the neurodevelopment theory. According to it, environmental factors, such as hypoxia, could cause alterations and abnormalities in cellular machinery, including modifications in neural proliferation, migration and differentiation, in addition to changes in synapsis formation, which could lead to degenerative processes. H…

  The role of sirtuins on mitochondrial function and neurogenesis in different cellular models of hypoxia: relevance to schizophrenia genesis and progression, BP.DR

• Abstract

  Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease, characterized by motor neuron death in the brain and the spinal cord. ALS manifests as sporadic (sALS) in most cases (around 90%) or familial (fALS) in around 10% of occurrences, which are related to genetic causes. Previous studies have already related ALS to a variety of factors such as inflammatio…

  The role of mitochondrial degradation to cellular homeostasis: a study in patients stem cells (iPSC) with familial Amyotrophic Lateral Sclerosis, BP.IC

• Abstract

  Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons. Mostly, ALS is a sporadic disease, and only between 10 to 15% of the cases is familial (due to genetic reasons; named ALSf). Nowadays it is known that ALS etiology is multifactorial, since it does not only present changes in genic expression and an increase in ubiqui…

  Functional studies in lymphocytes from Amyotrophic Lateral Sclerosis patients: relevance to biomarkers determination, BP.IC

(Only some records are available in English at this moment)