CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Daniel is an Associate Professor II of Biochemistry (Livre-Docente, MS 5.2) with expertise in mass spectrometrybased proteomic analysis (shotgun proteomics) and in silico systems biology, applied to clinical and preclinical models related to psychiatric disorders.He is an elected member of the General Faculty Bench of the Unicamp's University Council (CONSU) (20252027); between 20232025, he was the most voted MS5 faculty representative at CONSU. He served as one of the Coordinators of the Biology Area at FAPESP (20182025) and as a Member of the CNPq Advisory Committee, CA-BF (20222025). He was elected Affiliate Member of the Brazilian Academy of Sciences (20172021) and of the São Paulo State Academy of Sciences (20192023). He was Faculty Advisor to the Office of the Vice President for Research at Unicamp (20172021) and Head of the Department of Biochemistry and Tissue Biology (20222024).He established the Laboratory of Neuroproteomics in 2014, after returning from Germany, where he worked for two years as Principal Investigator at LMU Ludwig Maximilians Universität München (20122014). Daniel graduated in Biology (2003) and earned his PhD in Biochemistry (2008) at Unicamp. His postdoctoral training took place at the Max Planck Institute of Psychiatry in Germany (20082010) and at the University of Cambridge, UK (20102012), where he also led the Mass Spectrometry Group at the Cambridge Centre for Neuropsychiatric Research (CCNR). During the same period, he was a consultant for Psynova Neurotech Ltd. Daniel is a Founding Member of BrProt (2012) and served as a Board Member of BrMass (20142023). He was elected to the Council of the Human Proteome Organisation (20152017) and has been part of the Steering Committee of the Human Brain Proteome Project since 2015, serving as its Chair in 2023.He is Associate Editor of npj Schizophrenia (Nature), serves on the editorial boards of eight other scientific journals, and is permanent editor of the book series Proteomics, Metabolomics, Interactomics and Systems Biology (Springer-Nature, USA). He has delivered more than 60 oral presentations at international conferences, including as Plenary Speaker, Keynote Speaker, and Chair. His metrics include H-index 40 (ISI) and H-index 52 (Google Scholar), with more around 10,000 citations (Scholar). (Source: Lattes Curriculum)
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| Depression due to inflammation |
| Depresión por inflamación |
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Depression is a global cause of disability, affecting over 264 million people worldwide. In mice, the chronic exposure to a dominant conspecific, named social stress, is often used as a model to mimic behavioral outcomes perceived as "depression-like" responses. Although depression is highly studied, we are yet trying to understand the neural circuit changes or malfunctions that would lea…
Depression is a multifactorial and highly prevalent disorder with a significant socioeconomic impact and unsatisfactory therapeutic response in a considerable portion of patients. Its pathophysiology involves a complex network of neurobiological alterations, including dysfunctions in energy metabolism, neuroinflammation, and synaptic communication-processes in which neurons and astrocytes…
Psychiatric disorders rank among the most disabling health conditions worldwide, with Major Depressive Disorder (MDD) being the most prevalent and socially burdensome. Despite the availability of pharmacological treatments, a substantial proportion of patients either do not respond or only partially benefit from existing therapies, highlighting the urgent need to better understand the und…
(Only some records are available in English at this moment)
The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as a respiratory disease, SARS-CoV-2 infects multiple tissues throughout the human body, leading to a wide range of symptoms in patients. To better understand how SARS-CoV-2 affects the proteome from cells with different ontologies, this work generated an infectome atlas of 9 cell mode…
O Human Brain Proteome Project (HBPP) é uma iniciativa da HUPO (Human Proteome Organisation) que tem como objetivo revelar o proteoma cerebral em situações diversas, como saúde, doença ou trauma. Inicialmente fundado em 2004 e administrado com sucesso pelos pioneiros da neuroproteômica Helmut Meyer (Alemanha), Young-Mok Park (Coréia do Sul) e Joachim Klose (Alemanha), a partir de 2015, o …
Schizophrenia is a severe mental disorder that affects 0.7% of the worldwide population. The interactions between genetic and environment factors seem to be responsible for alterations in neurodevelopment, resulting in the manifestation of schizophrenia in late adolescence to early adulthood. The pathophysiology of schizophrenia is highly complex and involves several neurotransmission sys…
(Only some records are available in English at this moment)
Major depressive disorder (MDD) is a prevalent, heterogeneous, and highly disabling psychiatric condition. Several hypotheses currently seek to explain its pathophysiology; however, none fully explain the mechanisms that lead to its development. Among these hypotheses, the systemic inflammation hypothesis has gained prominence in recent decades due to the positive association between infl…
Psychiatric disorders involve complex neurobiological alterations, including dysfunctions in energy metabolism, a process in which different cell types of the nervous system play a crucial role. While recent evidence suggests mitochondrial alterations in the brains of patients with schizophrenia and depression, the specific role of the mitochondrial proteome remains to be further explored…
Intracellular and extracellular vesicles play a central role in cellular communication and protein trafficking, particularly in neurons. Alterations in vesicular dynamics and protein composition have been associated with different physiological and pathological contexts, including neuropsychiatric and neurodegenerative disorders. The SH-SY5Y cell line, widely used as an in vitro neuronal …
(Only some records are available in English at this moment)
O laboratório conta com a disponibilidade de 4 sistemas de cromatografia líquida, 3 dos quais estão acoplados a espectrômetros de massas. Esta infraestrutura é responsável por análises e validações de proteômica targeted e untargeted, metabolômica, lipidômica e tipos de preparo de amostra como depleção de proteínas abundantes e fracionamento de amostras que são realizadas no laboratório, …
Depression is considered the fourth leading cause of premature death and disability. This disease is commonly associated with depressed mood, anhedonia, changes in behavior and appetite, and reduced productivity at work. The main treatment is the administration of antidepressants from different classes. However, it is observed that up to 30% of patients using antidepressants do not experi…
Antipsicóticos atípicos são utilizados para o tratamento da esquizofrenia, que é uma doença psiquiátrica incurável que afeta mais de 30 milhões de pessoas no mundo. Tais antipsicóticos podem causar efeitos colaterais incluindo a síndrome metabólica, caracterizada por ganho rápido de peso, diabetes e problemas cardiovasculares, que normalmente surgem devido à disfunção do tecido adiposo. A…
(Only some records are available in English at this moment)
Neurodevelopmental conditions, such as Autism Spectrum Disorder (ASD) andSchizophrenia (SCZ), arise from a complex interplay between polygenic risk andenvironmental stressors. Maternal Immune Activation (MIA) is a major environmental riskfactor, with Interleukin-17A (IL-17A) serving as a key mediator of brain abnormalities.Microglia, the brain's resident immune cells, are central to this …
Psychiatric disorders like schizophrenia and depression have common underlying mechanisms including glutamatergic dysfunction, neuroinflammation, mitochondrial dysfunction, and their crosstalk. Impairment in autophagy, a cell survival process essential for cellular, energy and metabolic homeostasis, has been linked to these alterations. A promising drug candidate for psychiatric disorders…
Antipsychotics are a group of drugs used mainly to treat psychotic disorders like schizophrenia. Generally, they act as dopamine receptor agonists but also can affect adrenergic, serotonergic, cholinergic, and histamine receptors, which promote the management of a range of symptoms. Clozapine is considered one of the most effective antipsychotics. However, despite its benefits, clozapine …
Schizophrenia is a debilitating mental disorder, which affects approximately 1% of the world population, bringing a significant social and economic burden. Schizophrenia is a multifactorial disease associated with several gene/protein alterations that are highly influenced by environmental factors. Disease symptoms generally manifest in young adults when the neurodevelopment is at its end…
The brain is the most cholesterol-rich organ, accounting for 25% of the total cholesterol present in the human body, and is essential for synaptic transmission. Within the brain, myelin contains the majority of cholesterol, representing 70%, with the other 30% being present in the membranes of neurons and glial cells. Disturbances in cholesterol metabolism and levels are a risk factor for…
(Only some records are available in English at this moment)