CV Lattes
ResearcherID
ORCID
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Biological Sciences at the Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)(1965) and PhD in Genetics at the University of São Paulo (USP/FCMRP)(1969). Has experience in Genetics, focusing on Animal Genetics and Cell Biology, acting on the following subjects: Chromatin, Epigenetics, Silks and other Biopolymers, Special microscopies and Cytometry. (Source: Lattes Curriculum)
The action of Valproic Acid (VPA), a histone deacetylase inhibitor, has been investigated in several cell models under various experimental conditions. VPA has also been considered for clinical applications because of its modulating activity on gene expression. VPA affects different types of epigenetic marks through mechanisms that vary, depending on cell types and their physiological/pat…
Diabetes is a complex multifactorial disorder characterized by chronic hyperglycemia due to impaired insulin secretion. Recent observations suggest that the complexity of the disease cannot be entirely accounted for genetic predisposition and a compelling argument for an epigenetic component is rapidly emerging. The use of histone deacetylase inhibitor (HDACi) in clinical setting is an em…
Valproic acid (VPA), a well-known histone deacetylase inhibitor, has been reported to affect the DNA methylation status in addition to inducing histone hyperacetylation in several cell types. In HeLa cells, VPA promotes histone acetylation and chromatin remodeling. However, DNA demethylation was not checked in this cell model for standing effects longer than those provided by histone acet…
A previous study has not revealed the participation of a mucous component in the cocoon wall of the solitary bee, Lithurgus chrysurus, differing from the cocoon structure reported for many other bee species. However, uncertainty remains, because only the median and rear zones of this cocoon type have thus far been analyzed. Here, we studied the front zone of this cocoon, searching its com…
(Only some records are available in English at this moment)
The somatic cells of Triatoma infestans, a blood-sucking hemipteran, vector of Chagas Disease, exhibit conspicuous heterochromatic bodies (chromocenters) containing an AT-rich DNA. Treatment using sodium valproate/valproic acid (VPA), a well-known histone deacetylase inhibitor, induces chromatin remodeling in T. infestans chromoceneters. However, it is not accompanied by H3K9 and H4K8 ace…
Following abdominal injection of Triatoma infestans specimens with VPA solutions, the chromatin structure in Malpighian tubule cells is variably affected. Although unraveling of the very conspicuous heterochromatic body present in these cells has been induced, such an effect was detected only in a portion of the cellular population. In addition, no induction of histone acetylation at H3K9…
Valproic Acid (VPA) is a well known Histone Deacetylase (HDAC) inhibitor. Currently, in addition to HDAC inhibition, DNA demethylation is being considered as part of the VPA action on certain cell types. In the present work, the process of DNA demethylation following VPA treatment will be studied in detail in HeLa cells, in which chromatin remodeling attributed to HDAC inhibition has been…
The hyperglycemia caused by diabetes mellitus type I (DMTI) induces changes in polyploidy and chromatin structure of mouse hepatocytes. These changes may be related to modifications in the abundance and activity of key regulatory proteins like the DNA methyltransferases (DNMT) as well as in gene expression. In a project previously supported by FAPESP (Proc. 2012/16232-5) we have determine…
(Only some records are available in English at this moment)
Diabetes is a complex multifactorial disorder characterized by chronic hyperglycemia due to impaired insulin secretion, with numerous pathways influencing its progression. Recent observations suggest that the complexity of the disease cannot be entirely accounted for by genetic predisposition. A compelling argument for an epigenetic component is rapidly emerging. Changes in the epigenetic…
| 1 / 1 | Ongoing research grants |
| 25 / 21 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 16 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 44 / 31 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 23 |
| Citations | 162 |
| Cit./Article | 7.0 |
| Data from Web of Science | |
DA COSTA, THIAGO ALVES; DI GANGI, ROSARIA; THOME, RODOLFO; FELISBINO, MARINA BARRETO; BONFANTI, AMANDA PIRES; WATANABE ISHIKAWA, LARISSA LUMI; SARTORI, ALEXANDRINA; BURGER, EVA; VERINAUD, LIANA. Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. PLoS One, v. 11, n. 10, OCT 13 2016. Web of Science Citations: 1. (14/19492-3, 12/22131-7, 13/01401-9, 14/02631-0, 12/03238-5, 13/08194-9)
ALVARENGA, ELENICE M.; RODRIGUES, VERA L. C. C.; MORAES, ALBERTO S.; NAVES, LUISA S.; MONDIN, MATEUS; FELISBINO, MARINA B.; MELLO, MARIA LUIZA S.. Histone epigenetic marks in heterochromatin and euchromatin of the Chagas' disease vector, Triatoma infestans. ACTA HISTOCHEMICA, v. 118, n. 4, p. 401-412, 2016. Web of Science Citations: 3. (10/50015-6)
MARIA LUIZA S. MELLO; SÍLVYA S. MARIA; MARIA CRISTINA H. TAVARES. Heat shock-induced apoptosis in germ line cells of Triatoma infestans Klug. GENETICS AND MOLECULAR BIOLOGY, v. 23, n. 2, p. -, Jun. 2000.
FELISBINO, MARINA BARRETO; DA COSTA, THIAGO ALVES; VICCARI GATTI, MARIA SILVIA; SILVEIRA MELLO, MARIA LUIZA. Differential Response of Human Hepatocyte Chromatin to HDAC Inhibitors as a Function of Microenvironmental Glucose Level. Journal of Cellular Physiology, v. 231, n. 10, p. 2257-2265, OCT 2016. Web of Science Citations: 3. (10/50015-6, 12/03238-5)
IMPERADOR, CARLOS HENRIQUE L.; BARDELLA, VANESSA B.; DOS ANJOS, ELI HEBER M.; RODRIGUES, VERA L. C. C.; CABRAL-DE-MELLO, DIOGO C.; MELLO, MARIA LUIZA S.. Spatial Distribution of Heterochromatin Bodies in the Nuclei ofTriatoma infestans(Klug). Microscopy and Microanalysis, v. 26, n. 3, p. 567-574, JUN 2020. Web of Science Citations: 0. (15/10356-2)
MELLO, MARIA LUIZA S.; VIDAL, B. C.. Changes in the Infrared Microspectroscopic Characteristics of DNA Caused by Cationic Elements, Different Base Richness and Single-Stranded Form. PLoS One, v. 7, n. 8, AUG 24 2012. Web of Science Citations: 46. (10/50015-6)
ALVARENGA, ELENICE M.; MONDIN, MATEUS; RODRIGUES, VERA L. C. C.; ANDRADE, LARISSA M.; VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Contribution of AT-, GC-, and methylated cytidine-rich DNA to chromatin composition in Malpighian tubule cell nuclei of Panstrongylus megistus (Hemiptera, Reduviidae). ACTA HISTOCHEMICA, v. 114, n. 7, p. 665-672, 2012. Web of Science Citations: 2. (10/50015-6)
MELLO‚ M.L.S.; SILVYA S. MARIA‚ S.S.M.; SCHILDKNECHT‚ P.H.P.A.; GRAZZIOTIN‚ N.A.. DNA fragmentation in programmed cell death in nucleate erythrocytes: a cytochemical analysis. Acta Histochemica et Cytochemica, v. 33, n. 5, p. 355-359, 2000.
MELLO‚ M.L.S.; DE CAMPOS VIDAL‚ B.; LAREEF‚ M.H.; HU‚ Y.F.; YANG‚ X.; RUSSO‚ J.. DNA content‚ chromatin texture and nuclear morphology in benzo [a] pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17. Cytometry Part A, v. 52, n. 2, p. 70-76, 2003.
GHIRALDINI, FLAVIA GERELLI; VITOLO CRISPIM, ANA CAROLINA; SILVEIRA MELLO, MARIA LUIZA. Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes. MOLECULAR BIOLOGY OF THE CELL, v. 24, n. 15, p. 2467-2476, AUG 1 2013. Web of Science Citations: 15. (10/50015-6)
GHIRALDINI, FLAVIA G.; SILVEIRA, ANDRE B.; KLEINJAN, DIRK A.; GILBERT, NICK; MELLO, MARIA LUIZA S.. Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver. BMC Endocrine Disorders, v. 14, MAR 3 2014. Web of Science Citations: 3. (10/50015-6)
FELISBINO, MARINA BARRETO; VICCARI GATTI, MARIA SILVIA; MELLO, MARIA LUIZA S.. Changes in Chromatin Structure in NIH 3T3 Cells Induced by Valproic Acid and Trichostatin A. Journal of Cellular Biochemistry, v. 115, n. 11, p. 1937-1947, NOV 2014. Web of Science Citations: 15. (09/11763-0, 10/50015-6)
RODRIGUES, HENRIQUE F.; SOUZA, TAFAREL A.; GHIRALDINI, FLAVIA G.; MELLO, MARIA LUIZA S.; MORAES, ALBERTO S.. Increased Age Is Associated With Epigenetic and Structural Changes in Chromatin From Neuronal Nuclei. Journal of Cellular Biochemistry, v. 115, n. 4, p. 659-665, APR 2014. Web of Science Citations: 7. (10/50015-6)
VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Sodium valproate (VPA) interactions with DNA and histones. International Journal of Biological Macromolecules, v. 163, p. 219-231, NOV 15 2020. Web of Science Citations: 0. (15/10356-2)
VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Chiral supramolecular order revealed during the formation of calf thymus and phage DNA crystals. Micron, v. 102, p. 44-50, NOV 2017. Web of Science Citations: 1. (15/10356-2)
SILVA, ISABELA S.; GHIRALDINI, FLAVIA G.; VERONEZI, GIOVANA M. B.; MELLO, MARIA LUIZA S.. Polyploidy and nuclear phenotype characteristics of cardiomyocytes from diabetic adult and normoglycemic aged mice. ACTA HISTOCHEMICA, v. 120, n. 2, p. 84-94, 2018. Web of Science Citations: 2. (10/50015-6)
ALVARENGA, ELENICE M.; IMPERADOR, CARLOS H. L.; BARDELLA, VANESSA B.; RODRIGUES, VERA L. C. C.; MONDIN, MATEUS; CABRAL-DE-MELLO, DIOGO C.; MORAES, ALBERTO S.; MELLO, MARIA LUIZA S.. Histone acetylation and methylation marks in chromatin of Panstrongylus megistus (Hemiptera, Reduviidae). ACTA HISTOCHEMICA, v. 120, n. 6, p. 572-577, 2018. Web of Science Citations: 0. (10/50015-6, 15/10356-2)
MELLO, MARIA LUIZA S.; VIDAL, BENEDICTO DE CAMPOS. The Feulgen reaction: A brief review and new perspectives. ACTA HISTOCHEMICA, v. 119, n. 6, p. 603-609, 2017. Web of Science Citations: 5. (15/10356-2)
VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Toluidine blue staining for cell and tissue biology applications. ACTA HISTOCHEMICA, v. 121, n. 2, p. 101-112, 2019. Web of Science Citations: 2. (15/10356-2)
FELISBINO, MARINA BARRETO; TAMASHIRO, WIRLA M. S. C.; MELLO, MARIA LUIZA S.. Chromatin Remodeling, Cell Proliferation and Cell Death in Valproic Acid-Treated HeLa Cells. PLoS One, v. 6, n. 12, DEC 9 2011. Web of Science Citations: 20. (09/11763-0, 10/50015-6)
SILVA, ISABELA S.; GHIRALDINI, FLAVIA G.; VERONEZI, GIOVANA M. B.; MELLO, MARIA LUIZA S.. Polyploidy and nuclear phenotype characteristics of cardiomyocytes from diabetic adult and normoglycemic aged mice. ACTA HISTOCHEMICA, v. 120, n. 2, p. 84-94, 2018. Web of Science Citations: 2. (10/50015-6)
ALVARENGA, ELENICE M.; IMPERADOR, CARLOS H. L.; BARDELLA, VANESSA B.; RODRIGUES, VERA L. C. C.; MONDIN, MATEUS; CABRAL-DE-MELLO, DIOGO C.; MORAES, ALBERTO S.; MELLO, MARIA LUIZA S.. Histone acetylation and methylation marks in chromatin of Panstrongylus megistus (Hemiptera, Reduviidae). ACTA HISTOCHEMICA, v. 120, n. 6, p. 572-577, 2018. Web of Science Citations: 0. (10/50015-6, 15/10356-2)
MELLO, MARIA LUIZA S.; VIDAL, BENEDICTO DE CAMPOS. The Feulgen reaction: A brief review and new perspectives. ACTA HISTOCHEMICA, v. 119, n. 6, p. 603-609, 2017. Web of Science Citations: 5. (15/10356-2)
VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Chiral supramolecular order revealed during the formation of calf thymus and phage DNA crystals. Micron, v. 102, p. 44-50, NOV 2017. Web of Science Citations: 1. (15/10356-2)
VIDAL, BENEDICTO DE CAMPOS; MELLO, MARIA LUIZA S.. Toluidine blue staining for cell and tissue biology applications. ACTA HISTOCHEMICA, v. 121, n. 2, p. 101-112, 2019. Web of Science Citations: 2. (15/10356-2)
VERONEZI, GIOVANA M. B.; FELISBINO, MARINA BARRETO; GATTI, MARIA SILVIA V.; MELLO, MARIA LUIZA S.; VIDAL, BENEDICTO DE CAMPOS. DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy. PLoS One, v. 12, n. 1, JAN 23 2017. Web of Science Citations: 8. (14/23842-0)
ROCHA, MARINA AMORIM; BREDA VERONEZI, GIOVANA MARIA; FELISBINO, MARINA BARRETO; VICCARI GATTI, MARIA SILVIA; TAMASHIRO, WIRLA M. S. C.; SILVEIRA MELLO, MARIA LUIZA. Sodium valproate and 5-aza-2 `-deoxycytidine differentially modulate DNA demethylation in G1 phase-arrested and proliferative HeLa cells. SCIENTIFIC REPORTS, v. 9, DEC 3 2019. Web of Science Citations: 0. (14/23842-0, 15/10356-2)
(References retrieved automatically from State of São Paulo Research Institutions)
FELISBINO, Marina Barreto. Ação do ácido valproico e da tricostatina A na organização cromatínica e sua regulação por fatores epigenéticos em células HepG2 sob condições de hiperglicemia = Effects of valproic acid and trichostatin A on chromatin organization and its regulation by epigenetic factors in HepG2 cell grown under hyperglycemic conditions. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/03238-5)
VERONEZI, Giovana Maria Breda. A metilação de DNA em células HeLa após tratamento com o ácido valproico = The DNA methylation in HeLa cells after valproic acid treatment. Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (14/23842-0)
GARCIA, Simone Lopes. Sobrevivencia, ocorrencia de muda e fenotipos mucleares apos choque de temperatura em Panstrongylus megistus Burmeister. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (95/01954-8)
GARCIA, Simone Lopes. Termotolerancia e efeito do jejum, realimentação e infecção por Trypanosoma cruzi na resposta a choques de temperatura em Panstrongylus megistus (Burmeister). Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (98/00826-4)
FELISBINO, Marina Barreto. Remodelação cromatínica, anomalias cromossômicas e morte celular em condições de inibição de deacetilases de histonas em células HeLa e 3T3. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/11763-0)
GHIRALDINI, Flávia Gerelli. Efeitos do envelhecimento e do diabetes mellitus do tipo I sobre a estrutura da cromatina de hepatócitos de camundongos. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (08/58067-5)
TAVARES, Maria Cristina Henrique. Apoptose apos choque hipertermico em triatoma infestants (Klug) (Hemiptera, Reduviidae). Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (96/04783-2)
FALCO, Jose Ricardo Penteado. Caracterização citoquimica de complexos DNA-proteina contendo variantes de histona H1. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (95/02872-5)
MELLO, Maria Luiza Silveira. Distribuição espacial de corpos heterocromáticos em Triatoma infestans (Klug) e Panstrongylus megistus (Burmeister) : Spatial distribution of heterochromatic bodies in Triatoma infestans (Klug) and Panstrongylus megistus (Burmeister). Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (15/10356-2)