CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biology at University of Sao Paulo - Ribeirao Preto (1971); Master in Cardiovascular Physiology - Ribeirao Preto Medical School, University of São Paulo (1975); Ph.D. in Science - Ribeirão Preto Medical School , University of São Paulo (1979); Post-Doctoral Training at the Cleveland Clinic Educational Foundation, Cleveland OH, USA (1982-1983). Has experience in Cardiovascular Physiology and Exercise Physiology, working in the following areas: hypertension, heart failure, exercise training, with focus on baroreceptors and autonomic control of the circulation. She was Associate Professor at the Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo (1976-1989), working since 1990 at the Department of Physiology & Biophysics, Biomedical Sciences Institute, University of Sao Paulo (Full Professor of Physiology since 2003). (Source: Lattes Curriculum)
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Autonomic dysfunction and the consequent activation of the renin-angiotensin system are the main determinants of the deleterious effects of hypertension. Increased availability of angiotensin II (Ang II) within brain autonomic areas activates intracellular signaling pathways thus augmenting neuronal activity and resulting in sympathoexcitation that characterizes the neurogenic hypertensio…
Arterial hypertension (AH) is a chronic disease of high incidence that is accompanied by sympathetic hyperactivity and important imbalance of the autonomic circulatory control. Recent studies in hypertensive animals suggested that deleterious changes in brain perfusion, specifically in the blood-brain barrier (BBB) function, could contribute to the autonomic dysfunction and sympathetic hy…
There is considerable anecdotal evidence that a sedentary Iifestyle can lead to ill heath in old age, whereas physical activity has long-term health and wellbeing benefits. The reasons why homeostatic systems deteriorate in the elderly, and why exercise can ameliorate this deterioration, are not well understood. However, there is growing evidence that autonomic nervous system (ANS) imbala…
(Only some records are available in English at this moment)
The blood-brain barrier (BBB) rigidly controls the transit of substances between the plasma and the interstitium of brain areas. Microglia do not structure the BBB, but interfere with its functioning through the synthesis of pro-inflammatory cytokines. Experimental evidence has demonstrated in chronic hypertension microglial activation and BBB dysfunction with access of angiotensin II (An…
After proving that chronic hypertension was associated with dysfunction of the blood-brain barrier (BBB) and promoting deficits of autonomic control in important areas for the autonomic balance (BIANCARDI et al, 2014), our group demonstrated that both dysfunctions were reversed by aerobic training (BUTTLER et al, 2017). Recent researchs from our laboratory also observed that both the elev…
The blood-brain barrier (BBB) rigidly controls the transit of substances between the plasma and the interstitium of brain areas. Microglia do not structure the BBB, but interfere with its functioning through the synthesis of pro-inflammatory cytokines. Experimental evidence has demonstrated in chronic hypertension microglial activation and BBB dysfunction with access of angiotensin II (An…
We determined in the initial part of this project that: 1) angiotensin II is greatly involved in the lesion of Blood-Brain Barrier (BBB) exhibited by chronically hypertensive rats; 2) BBB dysfunction is accompanied by increased transcellular transport (transcytosis) across the endothelial cell; 3) these effects are partially corrected by exercise training. Knowing that an important functi…
(Only some records are available in English at this moment)
Níveis elevados de Angiotensina II (AngII) contribuem para a disfunção da barreira hematoencefálica (BHE) na hipertensão essencial por meio de mecanismos envolvendo a adaptação inadequada de componentes da membrana da BHE, inflamação e participação do sistema imune inato, entre outros. A disfunção da BHE induzida por AngII inicia um ciclo deletério que sustenta a fase crônica da hipertens…
| 23 / 14 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 35 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 0 | Completed scholarships abroad |
| 61 / 29 | All research grants and scholarships |
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