Abstract
We are using the pathogen Paracoccidioides brasiliensis as a fungal model to study extracellular membranous vesicles (exosome-like). We intend to isolate and characterize the vesicles, determine their composition in comparison with cell wall proteins, verify their immunomodulatory role, and the role of monohexosylceramide in their secretion mechanism. The importance of exocytic vesicles a…