Eduardo Colombari

• Abstract

  Obesity and Hypertension are the leading cause of death in the world. Obesity and overweight contribute to elevated blood pressure in many patients with essential Hypertension. Experimental and clinical studies indicate that Visceral Obesity induces Hypertension by increasing renal sodium reabsorption through multiple mechanisms including activation of the Sympathetic Nervous System (SNS)…

  Experimental pathophysiology: role of central mechanisms of the cardiovascular and respiratory control changes induced by experimental Hypertension and Obesity, BP.PD

• Abstract

  Recent evidence has demonstrated that Renovascular Hypertension is characterized not only by an increase in sympathetic activity and activation of the renin-angiotensin-aldosterone system, but also by a peripheral inflammation with increased levels of circulating pro-inflammatory cytokines. Although the conventional therapeutic approaches for hypertension have targeted a reduction of symp…

  Mechanisms and neural circuits involved in the interaction between peripheral inflammation and sympathoexcitation in Renovascular Hypertension, BP.PD

• Abstract

  Aldosterone is a mineralocorticoid produced by the suprarenal glands with several physiological functions including the regulation of blood electrolyte content and volume. Despite of the synthesis and release of aldosterone occurring during the hypovolemic state the most intense stimulus for its release is during hyperkalemia. Aldosterone acts by binding to the intracellular mineralocorti…

  Role of central aldosterone in the neural control of renal function, BP.MS

(Only some records are available in English at this moment)

• Abstract

  The nervous and immune systems interact in a bidirectional manner, but the precise mechanisms governing this interplay are still unclear. Recently, we identified a previously unrecognized mechanism of neuroimmune interaction in which peripheral sensory organs (i.e., the carotid bodies) can detect the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in the blood, activatin…

  Mechanisms of inflammation-induced sensitization of peripheral sensory systems, BE.EP.PD

• Abstract

  Water deprivation (WD) activates vasopressinergic neurons located in the hypothalamic supraoptic nucleus (SON) increasing the levels of vasopressin (VP) into the blood, which acts promoting vasoconstriction and urinary water retention. Previous studies have shown that neurons of SON express members of the cyclic nucleotide-gated family of ion channels like the hyperpolarization-activated …

  Excitatory role of the hyperpolarization-activated inward current in the electrical excitability of vasopressinergic supraoptic neurons after water deprivation, BE.EP.PD

• Abstract

  Aldosterone is a mineralocorticoid produced by the suprarenal glands with several physiological functions including the modulation of blood pressure and the water-electrolyte content of the internal medium. The synthesis and release of aldosterone occur in the hypovolemic and especially in the hyperkalemic state. Aldosterone acts through interaction with the mineralocorticoid receptor (MR…

  Effects of systemic hyperkalemia: neural HSD2 activation and water balance, BE.EP.MS

(Only some records are available in English at this moment)