CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Biological Sciences (Universidade Federal de São Paulo - 2004) and PhD in Microbiology and Immunology (Universidade Federal de São Paulo - 2011). Worked as a postdoctoral fellow at the Laboratory of Malaria and Vector, National Institutes of Health in Bethesda, USA (2013-2017). Currently is Adjunct Professor of Cell Biology, in the Department of Microbiology, Immunology and Parasitology of Universidade Federal de São Paulo (UNIFESP). Has experience in Molecular Biology, Parasitology and Cell Biology, mainly in nucleic acid manipulation, genetic modification of microorganisms (specifically Plasmodium falciparum, Plasmodium knowlesi, Plasmodium vivax, Trypanosoma cruzi and Escherichia coli) and in vitro and ex vivo cultures of human protozoan parasites (Plasmodium falciparum, Plasmodium knowlesi, Plasmodium vivax and Trypanosoma cruzi). Also has experience with non-human primate animal models, Rhesus monkeys, Aotus and Saimiri. (Source: Lattes Curriculum)
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Plasmodium vivax is the most predominant species outside Africa, and many countries aiming towards malaria elimination by 2030 are seeing an increase in resistance against chloroquine. The markers and mechanism of chloroquine resistance (CQR) remain unknown; hampering molecular surveillance and accurate diagnosis of CQR. Our hypothesis, based on our clinical study in Vietnam, published da…
Malaria is a major human parasitic disease, responsible for more than 200 million cases and around 500,000 deaths per year worldwide. Five species of Plasmodium cause human malaria: Plasmodium falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. P. falciparum, the main cause of deaths for malaria, receives most of the attention and investments in research and control, mainly due t…
Few transcriptional control elements have been identified in Plasmodium, and many are distinct from their eukaryotic counterparts. Members of the ApiAp2 Transcription Factor (TF) family were discovered and related to the development of sporozoites, ookinetes and gametocytes in P. berghei and P. falciparum. However, attempts to characterize P. vivax regulatory sequences using heterologous …
Gametocytes are sexual forms of plasmodium, responsible for transmission from the vertebrate to invertebrate hosts (Anopheles mosquitoes). Techniques for gametocyte development in vitro allowed the characterization of these forms of Plasmodium falciparum, the identification of molecular markers and studies of malaria transmission blocking drugs. However, gametocytes differences between Pl…
Malaria is responsible for more than 200 million cases and 400,000 deaths worldwide yearly. Five species of Plasmodium cause human infections: Plasmodium falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. The development of new antimalarial drugs is mandatory, as the parasites constantly develop drug resistance mechanisms and the action of compounds may vary between species. Thi…
For many years chloroquine (CQ) was the main drug against blood stages of malaria parasites. Introduced after World War II, the first reports of chloroquine-resistant Plasmodium falciparum appeared in 1957. Resistant parasites quickly spread to all endemic regions, resulting in the total removal of CQ for the treatment of P. falciparum infections in 2000. The first cases of P. vivax chlor…
(Only some records are available in English at this moment)
In vitro studies of Plasmodium falciparum sexual stages have revealed key processes by which gametocytes develop and transmit human infections to Anopheles mosquitoes. However, other human malaria species, such as Plasmodium vivax and Plasmodium knowlesi, exhibit distinct gametocyte biology, with different morphology, faster development and shorter lifespan compared to P. falciparum, refl…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 11 | All research grants and scholarships |
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