CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia Bioquímica from Universidade Federal de Santa Catarina (2002), master's at Farmácia from Universidade Federal de Santa Catarina (2003) and doctorate at Bioquímica from Universidade de São Paulo (2008). Has experience in Biochemistry, acting on the following subjects: estresse oxidativo, biodisponibilidade, monitoramento terapêutico, carvedilol and lipídios. (Source: Lattes Curriculum)
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Since 2016, the REDOX PROTEOMICS CORE, a multi-user laboratory associated with the Analytical Center of the Institute of Chemistry / USP, has been offering specialized proteomic analysis to users from the State of São Paulo, from other states and even internationally. This proposal requests an upgrade to the instrumentation dedicated to proteomic analyses available in REDOX PROTEOMICS COR…
Since pioneering clinical studies were performed in the 1970s, it is known that the levels of cholesterol (C) in high-density lipoprotein (HDL) correlate inversely with the chances of developing cardiovascular diseases. However, studies with drugs that increase the content of cholesterol in HDL (HDL-C, routinely measured in clinics) have had negative results, calling into check the import…
The inverse relationship between the levels of HDL cholesterol (HDL-C) and the risk of cardiovascular disease has been established for a long time. However, clinical trials that pharmacologically elevate HDL-C showed no clinical benefits. The HDL metric used by clinical laboratories - the amount of cholesterol - is limited, since it does not provide information about composition (except c…
Known in clinical medicine as "good cholesterol," HDL (High-Density Lipoprotein) is composed of a diverse collection of particles that vary in density, function, and lipidic and proteic content. In this way, the current clinical measurement of HDL particles in circulation - their cholesterol content (HDL-C) - fails to capture their compositional and functional complexity. The HDL proteome…
Macrophages are cells of the immune system with an important role in inflammatory processes and are generally studied using the THP-1 immortalized cell line as a model, however, how close these cells are to primary cells is unknown. High-density lipoprotein (HDL) has a relevant, but poorly understood, anti-inflammatory role, especially for these cells. Thus, the project proposes a compari…
Neutrophils and eosinophils are key leukocytes for the immune system. Neutrophils are the first cells that are recruited to inflammatory sites and are capable of orchestrate the immune response. Eosinophils also kill pathogens, mainly fungi and parasites. Moreover, they are associated with diseases such as Asthma, Rhinitis, and gastrointestinal infections. Both eosinophils and neutrophils…
This project aims to develop proteomics protocols applied to different types of samples, such as cell lysates, plasma, and biological tissues, using previously studied and optimized methodologies, and the use of this knowledge to evaluate the effect of high-density lipoprotein (HDL) in macrophages activated with bacterial lipopolysaccharide (LPS).
Among the plasma lipoproteins, the high-density lipoprotein (HDL) is considered atheroprotective because it is responsible for the removal of the excess of cholesterol from macrophages in the arterial walls, the so-called reverse cholesterol transport. However, other functions have also been attributed to this lipoprotein, such as the modulation of endothelial cells' response to an inflam…
Among the plasma lipoproteins, high-density lipoprotein(HDL) is responsible for removing excess cholesterol from macrophages in the artery walls in a process called reverse cholesterol transport. However, other important functions have been attributed to this lipoprotein. For instance, HDL has been shown to modulate the inflammatory response of activated macrophages. In this work, we aim …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 9 | Completed scholarships in Brazil |
| 18 / 15 | All research grants and scholarships |
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