Wothan Tavares de Lima

• Abstract

  Asthma and obesity are the two fastest growing conditions in the western world. Asthma is a chronic inflammatory disease of the airways that is commonly treated with steroidal and brochodilators. However, there is a portion of obese asthmatic patients who present resistance to steroid treatment and in this case the disease is classified as steroid-resistant asthma. These patients develop …

  Obesity, sex hormones and asthma Th1 and Th2, AP.R

• Abstract

  Sexual dimorphism modulates the profile of Th1 and Th2 lymphocytes, and accordingly sex hormones may modulate ALI by intestinal I/R. Studies indicate that gut of female is more resistant than the male to deleterious effects of ischemic injury. Here we investigated the effect of estradiol on the lung inflammation after intestinal I/R and its interaction with the NO pathway. Anesthetized ra…

  Protective effect of estradiol on acute lung inflammation induced by an intestinal ischemic insult is dependent on nitric oxide, PUB.ART

• Abstract

  Intestinal Ischemia and reperfusion (intestinal I/R) can cause local lesions, bacterial translocation, systemic inflammation and multiple organ failure. Notably, intestinal I/R is clinically relevant by triggering acute lung inflammation, which in severe cases may evolve to acute respiratory distress syndrome (ARDS). The etiology of intestinal I/R includes arterial embolism, arterial thro…

  Effect of intestinal ischemia and reperfusion on intestinal contraction, generation of inflammatory mediators and mesenteric microcirculation. role of gender and lymphatic system, AP.R

(Only some records are available in English at this moment)