CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Engenharia Química from Universidade de São Paulo (1979), master's at Chemical Engineering from Universidade Federal de São Carlos (1991) and ph.d. at Chemical Engineering from Universidade Federal de São Carlos (1996). Has experience in Chemical Engineering, focusing on Biochemical Processes, acting on the following subjects: streptomyces clavuligerus, ácido clavulânico, produção de cefalosporina c, cephalosporium acremonium and cinética de bioprocessos. (Source: Lattes Curriculum)
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The diversity of bioactive compounds produced by Streptomyces clavuligerus, several of them of great therapeutic interest (cephalosporins, clavulanic acid, holomycin, tunicamycin), made this species an excellent model to study the interrelationships of mechanisms governing secondary metabolism. There are many studies reporting separately discovery and/or elucidation of genes, enzymes, reg…
The project deals with the investigation of the necessary steps to develop biotechnology for the production of bioactive substances obtained from Streptomyces. For clavulanic acid, AC and cephamycin C, CefC the study intends to fully develop complete production process alternatives including: genetic improvement, bioprocess, and bioreactor development, and also downstream processes develo…
Streptomyces clavuligerus produces various secondary metabolites of therapeutic interest: clavulanic acid, a potent inhibitor of beta-lactamases, and twenty other clavams, several of them with antifungal activity; cephamycin C, a beta-lactam antibiotic used to produce several semi synthetic antibiotics with action against anaerobic bacteria; tunicamycin, a mixture of homologous nucleoside…
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| 6 / 2 | Completed scholarships in Brazil |
| 11 / 4 | All research grants and scholarships |
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