Vanessa da Silva Silveira

• Abstract

  Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with an extremely poor prognosis and overall five-year survival rate of only 5%. This is one of the most intractable cancers and represents the eighth leading cause of cancer-related death in the world. The limited survival rate is mainly due to no screening methods for early diagnosis and tumor invasiveness and metastati…

  Dual specificity phosphatases activity on map kinases signaling regulation: impact on pancreatic ductal adenocarcinoma metabolic reprogramming, AP.JP

• Activity of dual-specificity protein phosphatases (DUSPs) in control of map kinase activation: impact on metabolic reprogramming of pancreatic ductal adenocarcinoma, BP.TT

• Abstract

  Pancreatic Ductal Adenocarcinoma (PDAC) is a malignant tumor which affects the pancreatic ductal cells and corresponds to 4% of all malignant tumors. It is highly aggressive, with a very unfavorable diagnosis and represents the 7th cause of cancer death by year in the world. 95% of the tumors that affects the pancreas occurs in the ductal cells. Little is known yet about the molecular mec…

  Role of dual specificity phosphatases (DUSP) in the induction of oxidative stress in pancreatic adenocarcinoma cells, BP.IC
• Activity of dual-specificity protein phosphatases (DUSPs) in control of map kinase activation: impact on metabolic reprogramming of pancreatic ductal adenocarcinoma, BP.TT

(Only some records are available in English at this moment)

• Abstract

  Although the current treatment approach for childhood acute lymphoblastic leukemia (ALL) demonstrate successful rates, some subtypes of the disease remains a major challenge for oncologists. Among these cases are patients who present early resistance to induction chemotherapy. In order to better understand the molecular mechanisms involved in this process, this proposal aims at the invest…

  Ras signaling activation in acute lymphoblastic leukemia cells, BE.EP.PD