Alexandrina Sartori

• Abstract

  Multiple sclerosis is an autoimmune disease that affects the central nervous system (CNS) and has no cure yet. Recently, there have been major advances in the development of disease-modifying treatments and these new approaches include dietary factors. Evidences observed in patients and in experimental models indicate that fungal derivatives and vitamin A can contribute to the improvement…

  Therapeutic potential of fungal derivatives and vitamin A in an experimental model of multiple sclerosis, AP.R

• Abstract

  Multiple sclerosis (MS) is a progressive inflammatory disease that damages the central nervous system (CNS). The currently available therapies for MS are primarily focused in minimizing the progression of disability and reducing the number of relapses, therefore new prophylactic and therapeutic strategies for MS are necessary. In this context, the present study was designed to determine i…

  Tolerogenic efficacy of the association MOG/vitamin D analog or MOG/rapamycin on experimental autoimmune encephalomyelitis, AP.R

• Abstract

  Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which affects the joints. Most of current therapies for treating RA and other autoimmune diseases is based on the suppression of immune response in general, which increases susceptibility to infectious agents. The aim of this study is to define an immunomodulatory strategy for prophylaxis and/or therapy of RA. For this…

  Immunomodulatory strategies in experimental arthritis based on induction of specific tolerance by vitamin D3 and rapamycin, AP.R

(Only some records are available in English at this moment)

• Abstract

  Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS).Approximately 85% of patients have relapsing-remitting MS (RRMS) characterized by an initial neurological dysfunction event followed by remission and relapse episodes. Its immunopathogenesis is complex and involves the interplay of distinct autoreactive T cell subsets and innate immune…

  Therapeutic efficacy of the organic selenium /vitamin A association in a relapsing-remitting multiple sclerosis model, BP.IC

• Abstract

  Multiple sclerosis (MS) is a chronic and demyelinating disease of the central nervous system (CNS). MS immunophatogenesis involves Th1, Th17 and Tc autoreactive lymphocytes and also macrophages and microglial cells activation that release many pro-inflammatory mediators and free radicals. Current therapies do not determine disease cure and some subjects are refractory to therapies. Theref…

  Vitamin D, paricalcitol, glibenclamide and clofazimine: therapeutic and immunomodulatory potential in experimental autoimmune encephalomyelitis, BP.DR

• Abstract

  Multiple sclerosis (MS) is a progressive inflammatory disease that damages the central nervous system (CNS). Currently available therapies for MS are primarily focused in minimizing the progression of disability and reducing the number of relapses, therefore, new prophylactic and therapeutic strategies for MS are necessary. Most of the therapeutic strategies to control this disease are di…

  Therapeutic effect of the association of epicutaneous MOG and rapamycin on experimental autoimmune encephalomyelitis, BP.IC

(Only some records are available in English at this moment)