CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Chemistry from the Federal University of Rio de Janeiro (1981), Master in Biophysics, UFRJ (1987), and Doctorate in Biophysics, (1990) UFRJ with sandwich Doctorate and internships: Whitehead Institute, MIT in Boston (USA), University of Pacific, California (USA). Post-doctorate: King's College (England) and Babraham Institute in Cambridge (England) and at the National Institute of Bioscience and Human Technology in Tsukuba (Japan). Full Professor at USP (from 2001) and the Department of Clinical and Toxicological Analysis - FCF- University of São Paulo (2018-). Visiting Professor in the Department of Pathology, NYU (New York University), New York, USA (2004-2005) Adjunct Professor at Rutgers, The State University of New Jersey University (USA). Our research aims to investigate how chemical signals in the host-pathogen relationship modulate the malaria parasite cycle. The laboratory's main research lines include Screening of synthetic and natural compounds with a focus on the development of new drugs for the treatment of malaria. Membrane receptors of the GPCR (G protein-coupled receptor) type make up about 50% of the drug target in the pharmaceutical industry. We investigated Plasmodium falciparum GPCRs using a high throughput screening and cell imaging approach. For her work in malaria, she is a Fellow of the John Simon Guggenheim Memorial Foundation, a speaker at several international and national congresses. Associate Editor of Current Research in Microbial Sciences and a member of the editorial board of the journals: Molecular and Biochemical Parasitology, Methods X, Current Opinion in Microbiology, Current Topics in Medicinal Chemistry, Cellular and Molecular Life Sciences. Member of the CNPq editorial committee (2013-2018). Consultant to several national and international agencies: Welcome Trust, European Research Council, US-Israel Binational Science Foundation, Medical Research Council, Ministry of Science and Technology (MCT) in Portugal (2000 to 2002). Prof. Garcia coordinated the USP Research Center (NUSCEP) Cell signaling in the pathogen-host interaction (2012-2018). She is a full member of the Brazilian Academy of Sciences (2018), the World Academy of Sciences (TWAS - 2020), and the São Paulo State Academy (ACIESP) (2020). Fellow of the American Society for Cell Biology. President of the International Affairs Committee of the American Society for Cell Biology (ASCB) and advisor and collaborator of the Dean of Graduate Studies at the University of São Paulo (2019-). (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| A versatile parasite |
| More itemsLess items |
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Plasmodium falciparum is the responsible for the most severe form of malaria in humans, causing hundreds of thousands of deaths every year. Parasite transmission from humans to the mosquito vector is mediated by sexual stages (gametocytes) that are formed within the erythrocytes. Intracellular Ca2+ is a vital second messenger and controls several physiological processes in the Plasmodium …
Malaria stands as the third most dangerous infectious disease after HIV/AIDS and tuberculosis that afflict mankind. The last decade studies pointed that pathogen have developed sophisticated cell signaling networks that allow for both cell-cell communication as well as sensing the external environment. In this direction, single cell protozoan parasites have to develop systems to withstand…
Malaria stands as the third most dangerous infectious disease after HIV/AIDS and tuberculosis that afflict mankind. The last decade studies pointed that pathogens have developed sophisticated cell signaling networks that allow for both cell-cell communication as well as sensing the external environment. In this direction, single cell protozoan parasites have to develop systems to withstan…
(Only some records are available in English at this moment)
Cell Biology is the foundation to understand all aspects of the biological sciences. All aspects of organism development and function require the understanding of how the cells within each organism work. The central objective of our school is to expose students to hot topics in cell biology, namely host-pathogen interactions with focus on how cells transduces signals and, how cell divisio…
(Only some records are available in English at this moment)
Malaria is a disease caused by protozoan parasites of the genus Plasmodium that results in the death of hundreds of thousands of people every year. Due to the resistance that the etiological agent has acquired to available antimalarials, increasingly more research has been carried out into the biology of the parasite in order to elucidate its signaling pathways and discover targets for th…
Parasites of the genus Plasmodium are the causative agents of malaria, a disease that affects millions of people around the world annually. The emergence of parasites resistant to classic antimalarials used in the treatment of the disease points to the importance of understanding the biology of the parasite and looking for new targets for the development of new antimalarials. The synchron…
Malaria is an infectious disease caused by intracellular parasites of the genus Plasmodium. In humans, the infection can be caused by five species of the parasite and Plasmodium falciparum is responsible for the most severe form of the disease. Despite advances in the last decade resulting in a decrease in the number of cases, malaria is still responsible for causing more than 400,000 dea…
(Only some records are available in English at this moment)
Current antimalarial compounds are failing rapidly due to emerging drug resistance Plasmodium strains. This requires urgent discovery of new antimalarial compounds and novel targets in the parasites. Our lab has identified four serpentine receptor-like proteins, and which could be a potential target for malaria intervention. Moreover, we still know very little about the functionality of t…
The project described here aims the characterization of the serpentine receptor 12 (PfSR12) of Plasmodium falciparum parasites. Unlike what was described in literature by bioinformatics experiments that showed PfSR12 as a purinergic receptor, we did not observe release of Ca2+ in our HEK297T system after purine treatments, but we did see a statistically significant response in Ca2+ releas…
The histone-fold domain (HFD) is found in histones of eukaryotes and Archaea, but also in a family of proteins involved in transcriptional regulation, the so called NF-Y family. NF-Y is composed of three subunits: NF-YA, NF-YB and NF-YC. The B and C subunits each contains a HFD, and these two subunits form a tight dimer through the interaction of these domains. As a dimer they bind to DNA…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 20 / 13 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 56 / 26 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 88 / 51 | All research grants and scholarships |
| Associated processes | |