Abstract
Fumarate hydratases catalyze the stereospecific reversible hydration of fumarate to S-malate. The project aims to elucidate the mechanism of action of fumarate hydratase from Leishmania major by site directed mutagenesis, single crystal x-ray diffraction and electron paramagnetic resonance. Leishmania is a parasite that causes Leishmaniases, classified as neglected tropical deseases and t…