Abstract
The endoplasmic reticulum (ER) has two built-in mechanisms for controlling the quality of proteins that are in transit through secretory via: unfolded protein response (UPR) and endoplasmic reticulum-associated degradation (ERAD). Christianson and colleagues (2011) reported the involvement of human KIAA0090 gene in the formation of endoplasmic reticulum membrane complex (mEMC), previously…