CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmacia from Centro Universitario Barao de Maua (2004) and master's at Pharmacology from Universidade de São Paulo (2005). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: metalloproteinases, doxycycline, renovascular hypertension, vascular dysfunction and nitric oxide. (Source: Lattes Curriculum)
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Testosterone is the main pharmacological approach used by transmasculine individuals during gender-affirming hormone therapy (GAHT-T). Although presenting a safe profile, it can increase cardiovascular risk in this population. Of note, the literature lacks studies addressing the effects of testosterone, and related mechanisms, in the cardiovascular system of biological female organisms, e…
The inhibition of the maladaptive arterial remodeling contributes to prevent arterial hypertension. Earlier pharmacological intervention is important to control the incidence of such cardiovascular disease. Knowing that the quality of the intrauterine environment helps to develop hypertension, and the fetus is highly vulnerable to several insults, this period may be the most responsive to…
Hypertension significantly leads to vascular hypertrophic remodeling and dysfunction that usually precedes the development of many cardiovascular diseases. Increased matrix metalloproteinase (MMP)-2 activity contributes to cause vascular smooth muscle cells to hypertrophy and proliferate during the remodeling of hypertension. In fact, by inhibiting MMP activity, the incidence of the malad…
Arterial hypertension significantly leads to hypertrophic cardiac remodeling and dysfunction that usually proceed to heart failure. Increased activity of calpain and matrix metalloproteinase (MMP)-2 may contribute to hypertension-induced cardiac hypertrophy and systolic-diastolic dysfunction. Chronic treatment with subantimocrobial dosage of the MMP inhibitor, doxycycline, or calpastatin,…
(Only some records are available in English at this moment)
Preterm birth is associated with increased risk of cardiovascular diseases in adulthood, such as hypertension, and is characterized by respiratory distress syndrome, which increases morbidity and mortality in newborns. Prenatal treatment with corticosteroids is an alternative in cases of risk of preterm birth, as it accelerates fetal lung maturation. On the other hand, prolonged use of pr…
Obesity is a global public health problem and is associated with the secretion of pro-inflammatory adipokines that contribute to metabolic syndrome and associated cardiovascular diseases, such as hypertension. Visfatin is one of these adipokines and can cause oxidative stress in the vasculature. It is already known that oxidative stress contributes to arterial remodeling through different…
Hypertension is associated with inflammation and immune response and then the hypertensive patients have higher plasma concentrations of pro-inflammatory cytokines. The generation of reactive oxygen species (ROS), the expression and release of cytokines and chemokines, and the infiltration of immune cells in the kidneys and arteries is characteristic of hypertension. Oxidative stress may …
Matrix metalloproteinase (MMP)-2 degrades intracellular proteins that regulate the contraction of Vascular Smooth Muscle Cells (VSMCs), like calponin-1, and it is more active in rats two kidneys-one clip (2K-1C), being responsible for cell proliferation and arterial remodeling. The sarcoplasmic reticulum Ca2+-ATPase (SERCA) controls the concentration of calcium in the cytosol of VSMCs, wh…
Prematurity is associated with increased risks of cardiovascular diseases as hypertension in adult life. Angiotensin II contributes to increase the production of reactive oxygen species (ROS) and increase matrix metalloproteinase (MMP)-2 activity. MMP-2 proteolyzes extracellular matrix components and intracellular proteins in vascular smooth muscle cells and heart during hypertension, suc…
| 1 / 1 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 10 | All research grants and scholarships |
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