CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Sandra Marcia Muxel in research grants and scholarships supported by FAPESP.
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Understanding as parasite and host factors contribute to the pathogenesis of leishmaniasis is highly relevant to understanding the modulation of macrophage activation mediated by long noncoding RNA (lncRNA) and microRNAs (miRNAs). They can influence the transcriptional and post-transcriptional regulation of genes that can promote the survival or death of the parasite. The lncRNAs regulate…
The control of gene expression is a complex network that could be mediated by three regulators: 1) transcription factors (TFs), via binding to regulatory DNA regions such as promoters or enhancers in the target gene that regulated mRNA transcription; 2) long noncoding RNA (lncRNA), via interaction with DNA, RNA or protein, regulating the chromosomal structure, transcription of mRNAs and m…
Post-transcriptional regulation mediated by microRNAs in infectious processes caused by bacteria, viruses and parasites, as well as tumor cells, is intensively studied in recent years. The Leishmania infection is also able to modulate the expression of miRNAs and regulate genes involved in macrophage response to parasite. The Leishmania-modulation of miRNAs expression of macrophage could …
The hypothesis of this project is that the miRNA profile of macrophage can be altered during entry and replication of Leishmania amazonensis infection on macrophage, and can subvert the host immune response. In this way, the change in the miRNAs profile of macrophages, it is involved in the control of pos-transcriptional levels in the intracellular signaling the pathways of the innate imm…
Mammalian host infected with protozoan parasite Leishmania amazonensis causes a cutaneous leishmaniosis, a neglected disease that present a higher prevalence in Brazil. The establishment of immunological response uses post-transcriptional resources, such as microRNAs, which are largely studied in leishmaniasis. The ways to forward the control of gene expression regulation from polyamines …
The protozoan Leishmania can subvert the immune response against intracellular pathogens through the regulation of gene expression, such as transcriptional and post-transcriptional mechanisms for the establishment of the infection. The transcriptional mechanisms occur through the action of transcription factors, which can bind to the promoter region of the gene, inducing its transcription…
Leishmania is a protozoan parasite that is the causative agent of Leishmaniasis. This parasite alternate its life cycle between promastigotes inside the invertebrate host and amastigotes inhabiting immune phagocytic cells on the vertebrate host, among then, the macrophages. Parasites subvert the activation of macrophages microbicidal mechanisms, favoring the polyamines production by the A…
The dynamic and complex metabolic coupling established between Leishmania and its host results from a long co-evolutionary process. Due to the constant and sudden alterations imposed by the host microenvironment, such metabolic coupling continues to be dynamically regulated. The constant pursuit and competition for nutrients within the host-Leishmania duet will alter the host metabolic pa…
| 1 / 1 | Ongoing research grants |
| 6 / 3 | Completed research grants |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 8 | All research grants and scholarships |
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