CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual de Londrina (1985), master's at Genetics from Universidade Federal do Rio Grande do Sul (1990) and ph.d. at Biologia Molecular from Gesellshaft Fur Biotechnologische Forshung (1994). Has experience in Biochemistry, acting on the following subjects: interação proteína-proteína, processamento de rna, interação proteína-rna, saccharomyces cerevisiae and expressão gênica. (Source: Lattes Curriculum)
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In eukaryotes, ribosome synthesis is a high-energy demanding process initiated with the synthesis by RNA polymerase I of ribosomal RNA precursors (pre-rRNAs) in the nucleolus. These pre-rRNAs undergo processing reactions, including nucleotide modifications and endo- and exonucleolytic cleavages to form the mature rRNAs, which, together with ribosomal proteins generate the ribosomal subuni…
In eukaryotes, RNAs undergo many processing steps before becoming functional; these steps require specific protein-protein and protein-RNA interactions that are essential for the control of gene expression. We have characterized the function of various yeast proteins, involved in different steps of RNA processing. The RNase named exosome has been the main focus of the research in my group…
In eukaryotes, RNAs undergo many processing steps before becoming functional; these steps require specific protein-protein and protein-RNA interactions that are essential for the control of gene expression. We have characterized the function of various yeast proteins, involved in different steps of RNA processing. The RNase named exosome has been the main focus of the research in my group…
Ribosomal synthesis is a very energy demanding process that initiates with the transcription of precursor ribosomal RNAs (pre-rRNAs) in the nucleolus in eukaryotic cells. RNA polymerase I transcribes the pre-rRNA that contains the sequences of 18S, 5.8S and 25/28S rRNAs, whereas RNA pol III transcribes pre-5S rRNA. These pre-rRNAs undergo many processing reactions that include nucleotide …
Eukaryotic ribosome biogenesis is an elaborate process during which ribosomal proteins assemble with the pre-rRNA while it is being processed and folded. Hundreds of assembly factors (AF) are required and transiently recruited to assist the sequential remodeling events. One of the most intricate ones is the stepwise removal of the internal transcribed spacer 2 (ITS2), between the 5.8S and…
(Only some records are available in English at this moment)
The small nuclear RNA (snRNA) U2 is an essential component of the spliceosome that interacts directly with conserved sequences in pre-mRNA during splicing. The role of U2 snRNA extends from the assembly of the pre-spliceosome, through its activation and catalysis, to the disassembling of the complex and involves various changes in its structure. The formation of the small nuclear ribonucl…
The RNA exosome is a multisubunit complex responsible for processing and degradation of all classes of RNA. This eukaryotic complex is present in nucleus and cytoplasm, and formed by eleven protein subunits, two of them, catalytically active. In humans, the catalytic subunit DIS3 is also associated with control of cell cycle, and inhibition of its function, caused by mutations in its exor…
The ribosome is a complex and essential molecular machinery for all organisms, as it is responsible for translating information encoded in genomes for protein synthesis in cells. Ribosomal biogenesis is a process that involves multiple steps of processing and maturation of ribosomal RNAs and their association with proteins for the formation of 60S and 40S subunits in eukaryotes. The yeast…
(Only some records are available in English at this moment)
The RNA exosome is a ribonucleolytic complex formed by the association of differentsubunits. Because of its exoribonuclease 3'à5' catalytic activity, the exosome controls thelevels of all classes of RNAs, regulating the chromatin structure, gene expression, celldifferentiation and ribosome biogenesis. In this context, this RNase has been the main focus ofresearch in our laboratory. The ex…
Most eukaryotic genes contain non-coding sequences, called introns, that are removed during splicing. This maturation process is carried out by the spliceosome in conjunction with hundreds of evolutionarily conserved factors, including the Cwc24 protein, which binds to the 5' end of the intron, protecting it. The binding of Cwc24 to the pre-mRNA and the spliceosome is temporary, but its a…
Protein phosphorylation regulates the activity, localization, stability, and interaction with other ligands. The process of ribosomal biogenesis is highly complex, being dynamically controlled by the action of specific protein-protein and RNA-protein interactions, which are essential for the control of gene expression. The RNase called exosome has been the central focus of research of our…
(Only some records are available in English at this moment)
The spliceosome is a large RNA-protein complex responsible for catalyzing the splicing reactions of pre-RNAs in eukaryotes. The spliceosome protein Cwc24 plays an important role in splicing regulation by binding the 5' splicing site (5'SS), and protecting this site from premature reactions. Our laboratory has shown that Cwc24 is a general splicing factor and that splicing of U3 snoRNA is …
The exosome is a multiprotein complex that plays an important role in the processing and degradation of all classes of RNAs in the nucleus and cytoplasm. In Saccharomyces cerevisiae cells, it is formed by 10 subunits in the cytosol (EXO10), and by 11 subunits in the nucleus (EXO11). In the cytosol, the EXO10 acts in the regulation of specific RNA expression levels associated with the Ski …
Regulation of the expression of genes essential for development is mediated by the correct metabolism of RNAs and the exosome, a highly conserved ribonuclease in eukaryotes, is involved in processing, maturation, and quality control of several classes of RNAs. Altering amino acids in the structure of the exosome subunits and their consequent loss of function in RNA processing can cause sp…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 18 / 12 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 29 / 15 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 62 / 41 | All research grants and scholarships |
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