Clarice Kazue Fujihara

• Abstract

  Chronic Kidney Disease (CKD) involves the participation of a series of inflammatory events that culminate in fibrosis of the renal parenchyma. The reasons why these processes, which involve the activation of phenomena related to adaptive immunity, are triggered in the absence of microbial antigens or other foreign proteins are uncertain. With the new knowledge about the innate immunity, a…

  Pathogenesis and treatment of chronic kidney disease: role of innate immunity in glomerular, tubular and interstitial injury, AP.TEM

• Abstract

  Despite the undeniable advances verified in the last twenty years, the mechanisms involved in the progression of chronic kidney disease (CKD) to the stage of advanced renal insufficiency are still far from being fully understood. It is known, however, that the tubulointerstitial fibrosis constitutes a final common pathway for a series of processes that cause CKD. Some of these originate i…

  Experimental chronic kidney disease by dietary adenine overload: initial tubular injury, mechanism of granuloma formation and prevention of fibrosis, AP.R

• Abstract

  The role of new vessel formation in the pathogenesis of chronic kidney disease (CKD) is currently unclear and has fueled a heated controversy. Part of the available evidence suggests that neoangiogenesis exerts a beneficial effect in CKD, acting in the process of reconstruction and reorganization of the damaged tissue. However, other experimental findings indicate that new capillary forma…

  The effects of anti-angiogenesis agent, malato de sunitinib (Sutent), administration in the 5/6 renal ablation (Nx) model, AP.R

• Role of the TLR4/NFkB system and the NLRP3 inflammatory pathways in prolonged exposure of tubular cells to elevated albumin concentrations, BP.TT

• Abstract

  Chronic Kidney Disease (CKD) involves the participation of the several inflammatory events that end in fibrosis of renal interstitial even if the process has started only in the glomeruli. One of the biggest challenges of the nephrology is to stop the progression of nephropathy. In the clinical context, proteinuria correlates with progression of kidney diseases, in particular glomerular d…

  A treatment using a component of innate immunity inhibitor on adriamycin nephropathy, BP.IC

• Abstract

  Chronic nitric oxide synthase inhibition by NW -nitro- L-arginine methyl ester (L-NAME) associated with salt overload (HS) is a model of chronic kidney disease (CKD), originally described in our laboratory. This model has been used widely to understand the mechanisms that are involved in the progression of CKD, currently a major public health problem. In our initial description and in sub…

  Role of NFkB system and NLRP3 inflammasome in the chronic inhibition of nitric oxide model, BP.MS

(Only some records are available in English at this moment)