CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1982), master's at Physiology from Universidade de São Paulo (1990) and ph.d. at Physiology from Universidade de São Paulo (1996). Has experience in Medicine, focusing on Nefrology, acting on the following subjects: inflamação renal, nefropatia progressiva, angiotensina ii, hemodinâmica glomerular and ablação renal. (Source: Lattes Curriculum)
Chronic Kidney Disease (CKD) involves the participation of a series of inflammatory events that culminate in fibrosis of the renal parenchyma. The reasons why these processes, which involve the activation of phenomena related to adaptive immunity, are triggered in the absence of microbial antigens or other foreign proteins are uncertain. With the new knowledge about the innate immunity, a…
Despite the undeniable advances verified in the last twenty years, the mechanisms involved in the progression of chronic kidney disease (CKD) to the stage of advanced renal insufficiency are still far from being fully understood. It is known, however, that the tubulointerstitial fibrosis constitutes a final common pathway for a series of processes that cause CKD. Some of these originate i…
The role of new vessel formation in the pathogenesis of chronic kidney disease (CKD) is currently unclear and has fueled a heated controversy. Part of the available evidence suggests that neoangiogenesis exerts a beneficial effect in CKD, acting in the process of reconstruction and reorganization of the damaged tissue. However, other experimental findings indicate that new capillary forma…
Chronic Kidney Disease (CKD) involves the participation of the several inflammatory events that end in fibrosis of renal interstitial even if the process has started only in the glomeruli. One of the biggest challenges of the nephrology is to stop the progression of nephropathy. In the clinical context, proteinuria correlates with progression of kidney diseases, in particular glomerular d…
Innate immunity components analysis in renal tissue of rats with glomerular hypertension Chronic kidney disease (CKD) can be initiated by mechanical action as a consequence of glomerular hypertension and hyperflow, immune, toxic or a decrease in the glomerular permeability. Subsequently, we observed an intense cell proliferation, excessive extracellular matrix production, cytokines, growt…
(Only some records are available in English at this moment)
| 8 / 3 | Completed research grants |
| 22 / 8 | Completed scholarships in Brazil |
| 30 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 58 |
| Cit./Article | 5.8 |
| Data from Web of Science | |
FORESTO-NETO, ORESTES; AVILA, VICTOR FERREIRA; ALARCON ARIAS, SIMONE COSTA; FREGNAN ZAMBOM, FERNANDA FLORENCIA; TONO REMPEL, LISIENNY CAMPOLI; FAUSTINO, VIVIANE DIAS; MACHADO, FLAVIA GOMES; AVANCINI COSTA MALHEIROS, DENISE MARIA; ABENSUR, HUGO; SARAIVA CAMARA, NIELS OLSEN; et al. NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model. LABORATORY INVESTIGATION, v. 98, n. 6, p. 773-782, JUN 2018. Web of Science Citations: 6. (12/10926-5, 13/12256-0, 11/19576-4)
FAUSTINO, VIVIANE DIAS; ALARCON ARIAS, SIMONE COSTA; AVILA, VICTOR FERREIRA; FORESTO-NETO, ORESTES; FREGNAN ZAMBOM, FERNANDA FLORENCIA; MACHADO, FLAVIA GOMES; DOS REIS, LUCIENE MACHADO; MARIA, DENISE; MALHEIROS, AVANCINI COSTA; VOLPINI, RILDO APARECIDO; et al. Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria. BIOSCIENCE REPORTS, v. 38, n. 4, AUG 31 2018. Web of Science Citations: 3. (12/10926-5, 13/11929-0)
FUJIHARA, CLARICE KAZUE; VIEIRA, JR., JOSE MAURO; SENA, CLAUDIA RAMOS; VENTURA, BIANCA HELENA; MALHEIROS, DENISE MARIA; ZATZ, ROBERTO. Early Brief Treatment with Losartan plus Mycophenolate Mofetil Provides Lasting Renoprotection in a Renal Ablation Model. AMERICAN JOURNAL OF NEPHROLOGY, v. 32, n. 2, p. 95-102, 2010. Web of Science Citations: 2.
UTIMURA‚ R.; FUJIHARA‚ C.K.; MATTAR‚ A.L.; MALHEIROS‚ D.M.A.C.; NORONHA‚ I.D.L.; ZATZ‚ R.. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes1. Kidney International, v. 63, n. 1, p. 209-216, 2003.
FUJIHARA‚ C.K.; ANTUNES‚ G.R.; MATTAR‚ A.L.; ANDREOLI‚ N.; AVANCINI‚ D.M.; MALHEIROS‚ C.; NORONHA‚ I.L.; ZATZ‚ R.. Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney. Kidney International, v. 64, n. 6, p. 2172-2181, 2003.
FUJIHARA‚ C.K.; AVANCINI COSTA MALHEIROS‚ D.M.; DE LOURDES NORONHA‚ I.; DE NUCCI‚ G.; ZATZ‚ R.. Mycophenolate mofetil reduces renal injury in the chronic nitric oxide synthase inhibition model. Hypertension, v. 37, n. 1, p. 170-175, 2001.
ALARCON ARIAS, SIMONE COSTA; VALENTE, CARLA PEREZ; MACHADO, FLAVIA GOMES; FANELLI, CAMILLA; TAEMI ORIGASSA, CLARICE SILVIA; DE BRITO, THALES; SARAIVA CAMARA, NIELS OLSEN; AVANCINI COSTA MALHEIROS, DENISE MARIA; ZATZ, ROBERTO; FUJIHARA, CLARICE KAZUE. Regression of Albuminuria and Hypertension and Arrest of Severe Renal Injury by a Losartan-Hydrochlorothiazide Association in a Model of Very Advanced Nephropathy. PLoS One, v. 8, n. 2, FEB 19 2013. Web of Science Citations: 15.
FUJIHARA‚ C.K.; VELHO‚ M.; MALHEIROS‚ D.M.C.; ZATZ‚ R.. An extremely high dose of losartan affords superior renoprotection in the remnant model. Kidney International, v. 67, n. 5, p. 1913-1924, 2005.
FREGNAN ZAMBOM, FERNANDA FLORENCIA; OLIVEIRA, KARIN CARNEIRO; FORESTO-NETO, ORESTES; FAUSTINO, VIVIANE DIAS; AVILA, VICTOR FERREIRA; ALBINO, AMANDA HELEN; ALARCON ARIAS, SIMONE COSTA; VOLPINI, RILDO APARECIDO; AVANCINI COSTA MALHEIROS, DENISE MARIA; SARAIVA CAMARA, NIELS OLSEN; et al. Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 317, n. 4, p. F1058-F1067, OCT 2019. Web of Science Citations: 0. (15/25368-6, 12/10926-5)
OKABE, CRISTIENE; BORGES, RAQUEL LERNER; DE ALMEIDA, DANILO CANDIDO; FANELLI, CAMILLA; BARLETTE, GRASIELA PEDREIRA; MACHADO, FLAVIA GOMES; ALARCON ARIAS, SIMONE COSTA; AVANCINI COSTA MALHEIROS, DENISE MARIA; SARAIVA CAMARA, NIELS OLSEN; ZATZ, ROBERTO; et al. NF-kappa B activation mediates crystal translocation and interstitial inflammation in adenine overload nephropathy. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 305, n. 2, p. F155-F163, JUL 2013. Web of Science Citations: 13. (11/10943-4, 12/08775-9)
MACHADO, FLAVIA G.; KURIKI, PATRICIA SEMEDO; FUJIHARA, CLARICE K.; FANELLI, CAMILLA; ARIAS, SIMONE C. A.; MALHEIROS, DENISE M. A. C.; CAMARA, NIELS O. S.; ZATZ, ROBERTO. Chronic VEGF Blockade Worsens Glomerular Injury in the Remnant Kidney Model. PLoS One, v. 7, n. 6, JUN 22 2012. Web of Science Citations: 15. (11/10943-4)
FANELLI, C.; FERNANDES, B. H. V.; MACHADO, F. G.; OKABE, C.; MALHEIROS, D. M. A. C.; FUJIHARA, C. K.; ZATZ, R.. Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 301, n. 3, p. F580-F587, SEP 2011. Web of Science Citations: 4.
(References retrieved automatically from State of São Paulo Research Institutions)
MACHADO, Flavia Gomes. Mecanismos de lesão renal progressiva decorrente do tratamento com losartan durante a lactação. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (05/51716-0)
FAUSTINO, Viviane Dias. Efeito de uma disfunção da barreira glomerular sobre a imunidade inata de células tubulares proximais. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (13/11929-0)
ZAMBOM, Fernanda Florencia Fregnan. A inibição das vias TLR4/NF-kB e do NLRP3/IL-1beta previne a DRC em um modelo de inibição crônica de NO associado à sobrecarga de sal. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (15/25368-6)