Abstract
Chronic kidney disease (CKD) is the result of progressive loss of functional nephrons. Regardless of the initial insult, CKD manifests itself as glomerulosclerosis, vascular sclerosis and tubulointerstitial fibrosis. It is believed that this last change is the best predictor of decline in renal function and poor prognosis. The tubulointerstitial fibrosis is characterized by accumulation o…