CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's degree in Biomedicine completed in 2012 by the Methodist University of São Paulo. Master in Cellular and Developmental Biology completed in 2015 by the University of São Paulo and PhD by the same university and in the same area completed in 2020 with a 6 (six) month internship in the laboratory of Professor Dr. Louis Hodgson from the Albert Einstein College of Medicine of Yeshiva University in New York, United States. Experience of 2 (two) years as a professor, from 2020 to 2022, at Estácio de São Paulo and Univeritas universities. I am currently doing postdoctoral work at the Albert Einstein College of Medicine, working mainly on the following topics: extracellular matrix, cell migration and cancer. (Source: Lattes Curriculum)
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Ovarian carcinoma is the leading cause of gynecological neoplastic death, being associated primarily with deregulation of sex hormones. The progression of cancer depends not only on abilities acquired by cancer cells, but also the interaction between cells and their microenvironment. The components of the extracellular matrix (ECM) are involved in several aspects of tumor biology, providi…
Sex hormones modulate various activities in cancer, since influencing the process of tumorigenesis, cell growth and metastasis. The ADAMTS's (a disintegrin and metalloproteinase with Thrombospondin Thrombospondin-adamalysin or motifs) are secreted proteases and are involved in functions such as the processing of procollagen to collagen N-proteinase cleavage of the proteoglycan matrix and …
The progression of cancer depends on the interaction between the cells and their microenvironment. ADAMTSs (adamalysin-thrombospondin) are secreted proteases dependent on Zn2+/Ca2+ and participate in many physiological and pathological processes. Progesterone increases ADAMTSs gene and protein expression and reduces the migratory and invasive capacity of the ovary cells when compared to u…
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