Abstract
Highly Active Antiretroviral Therapy (HAART) has been shown great results. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are widely used as first-line therapy. In Brazil, the therapy comprises the first-generation NNRTIs, nevirapine, and efavirenz, and also the second-generation NNRTI, etravirine. These drugs change the HIV-1 reverse transcriptase conformation, an alteration th…