CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciencias Biologicas from Universidade Estadual Paulista Júlio de Mesquita Filho (2003), master's at General Biology from Universidade Estadual de Campinas (2006) and doctorate at General Biology from Universidade Estadual de Campinas (2010). Has experience in Morphology, acting on the following subjects: desenvolvimento, prostata, canalização, câncer and matriz extracelular. (Source: Lattes Curriculum)
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What distinguishes quiescence/dormancy and senescence at the molecular level in normal and tumor cells? Quiescence is defined as a state of reversible cell cycle inactivity. Dormancy refers to quiescent tumor cells that reside in primary sites or distant organs and are responsible for cancer recurrence and metastatic disease after surgery and chemotherapy. Senescent cells, on the other ha…
The Hippo pathway plays central roles in the regulation of cell proliferation, apoptosis, organ size control, mechanotransduction and in turmorigenesis. In mammalians, Hippo consists fundamentally in 4 serine-threonine quinases: Mammalian Ste-20-like Kinase 1/2 (MST1, MST2) and large tumor suppressor 1/2 (LATS1, LATS2). Hippo activation culminates with phosphorylation, cytoplasmic retenti…
Fluorescence and transmitted light microscope with automated lateral and axial movement, equipped with CO2 incubator system for high-content imaging and capture of 3D images of living and fixed samples (AU)
Cell behavior and tissue homeostasis are not exclusively controlled by soluble chemical signals. Microenvironmental factors such as the extracellular matrix (ECM) arrangement, tissue architecture and mechanical forces are sources of signals capable of determining a cell's fate. Hippo-YAP (Hippo is a cascade of kinases that inactivate YAP, which is a transcription co-activator) regulates o…
Cyclin-dependent kinases (Cdks) play a fundamental role in regulating the progression of the cell cycle. Imbalances in Cdk activity can lead to excessive growth or tissue function failure. A useful tool for monitoring and quantifying Cdk activity at the single-cell level is the use of fluorescent sensors. These sensors are composed of a fluorescent protein, peptide segments containing pho…
Hippo is a tumor suppressor pathway and is related to the regulation of cell proliferation, apoptosis, organ size and tumorigenesis. In mammals, the Hippo pathway core is composed of 4 serine-threonine kinases: Mammalian Ste-20-like Kinase 1 and 2 (MST1 and MST2) and large suppressive tumor 1 and 2 (LATS1 and LATS2). When Hippo is active, the transcription co-activators YAP and TAZ are ph…
Proliferation is the most conserved and fundamental attribute of a living system. It is the propagation of genetic material through cell division, more than any other factors that distinguish life from inanimate natural systems. However, most cells in our body are not dividing, but are in a state of quiescence. Why then did quiescence triumph during evolution and how is it controlled? We …
Actin, a cytoskeleton protein, is involved in many cellular processes and can also be found inside the nucleus. Actin can assume the globular monomeric form (G-actin) or the filamentous form (F-actin) through polymerization, and the different forms of actin can also have different roles. In the nucleus, the roles played by the different forms of actin are not well understood and the regul…
(Only some records are available in English at this moment)
The cell cycle is traditionally studied by means of forcing synchronization in specific cell-cycle phases as well as bulk biochemistry of cells grown on bidimensional surfaces. However, cell proliferation occurs in tridimensional microenvironments within organisms and is rarely synchronized. Recently developed cell-cycle sensors and high-speed 4D microscopy have been overcoming these barr…
Chemical and mechanical signals from the basement membrane (BM), an extracellular matrix compartment (ECM), reprogram gene expression leading to quiescence and differentiation of mammary gland epithelial cells. Hippo-YAP, a pathway that regulates organ growth and size, act as a "relay" for mechanical signals from the microenvironment. It is known that the inhibition of HIPPO kinases allow…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 13 / 13 | All research grants and scholarships |
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