Abstract
Relaxin is an insulin-related peptide that interacts with the G-protein coupled receptor RXFP1. The male mice with a relaxin knockout is infertile, and previous studies from our laboratory revealed that relaxin and RXFP1 are expressed in germ cells, and relaxin stimulates the proliferation of Sertoli cells through a mechanism that involves activation of MEK/ERK1/2 and PI3K/AKT pathways. T…