Abstract
The B1 cells are found predominantly in the peritoneal and pleural cavities and are largely responsible for the production of low-affinity IgM, poly-reactive. Follicular B2 cells after follicular dendritic cell (fDC) and follicular T cell (FTH) undergo a series of processes in the germinal center (GC) where occurs immunoglobulin class switching and affinity maturation of antibodies provid…