Abstract
The hypoxia-inducible transcription factors (HIF), closely linked to disorders that lead top the progression of cancer, consist of two multidomain subunits including the constitutively expressed HIF-1² and an oxygen-labile HIF-1± (or paralogs HIF-2± and -3±). The heterodimeric complex controls the homeostatic and systemic responses to oxygen availability within the cell. In the presence …