Abstract
Growth hormone (GH) has several metabolic effects, including an anti-insulin or diabetogenic action. Consequently, excessive GH secretion induces insulin resistance and may predispose an individual to diabetes mellitus. In a study under review in PNAS, we show that ablation of the GH receptor (GHR) in Sim1-expressing cells, which include the hypothalamic paraventricular nucleus (PVH), led…