Abstract
Translational control mediated by the phosphorylation of initiation factor 2 (eIF2) is crucial for the adaptation of cells to different stress conditions, and malfunction of this signal pathway can lead to important pathologies. One of the four eIF2 kinases in mammals, GCN2, regulates de expression of large number of genes in response to e.g., amino acid deprivation. GCN2 also determines …