Graduated in Nutrition - Universidade Paulista (UNIP), Graduated in Biological Sciences - Bachelor and Degree - Faculty of Philosophy, Sciences and Letters of Ribeirão Preto (University of São Paulo - USP). Titled Master (2017) and Doctor (2023) in Sciences in the area of Internal Medicine, emphasis in Biomedical Research by the Faculty of Medicine of Ribeirão Preto (FMRP-USP). Specialization in Molecular Biology and Genetics in Health Sciences by FAMERP. Currently enrolled in the lato sensu postgraduate course in Nutrition in Women's Health and Human Reproduction at the LG Institute (PUC-GO) and in Clinical Nutrition in Gastroenterology at the VP College. Research experience in onco-hematology, molecular biology, genetics and metabolism, with an emphasis on insulin signaling pathways. (Source: Lattes Curriculum)
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Hematopoiesis regulation depends, among other factors, on the action of cytoplasmic adapter proteins, such as insulin receptor substrates (IRS). Previous study conducted by our research group indicated that IRS1 and IRS2 are differentially expressed in hematological malignancies, including myelodysplastic syndromes and acute leukemias. Our group also demonstrated that IRS2 is recruited du…
The identification of the JAK2V617F mutation as a molecular marker for myeloproliferative neoplasms represents a milestone in the progress in the diagnosis of these diseases as well as for the development of JAK2 pharmacological inhibitors. However, the isolated treatment with JAK2 inhibitors, such as ruxolitinib, is not specific for the mutated JAK2 and does not result in significant bet…
The identification of mutations in genes involved in the pathophysiology of hematologic malignancies may be an effective method for classification, diagnosis and assessment of prognosis of each patient. Myelodysplastic syndromes are a diverse group of clonal hematopoietic disorders, and its pathogenesis is related to a group of molecular changes. Some of these mutations result in constitu…
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