Abstract
Cardiotoxicity induced by doxorubicin (DOX), an anthracycline isolated from Streptomyces peucetius, is one of the main secondary pathophisiological events related to this antineoplasic compound. Cell death resulting from the toxic conditions is associated to deregulate metabolic mechanisms. Intracellular calcium flux and mitochondrial permeability seem to be important factors for cell dea…