Abstract
Fatty acid synthase (FASN) enzyme is responsible for the endogenous synthesis of long chain fatty acids from acetyl-CoA and malonyl-CoA. Structurally, FASN has two polypeptide chains with seven different domains in each. In contrast with normal tissues, FASN is overexpressed in several types of epithelial malignancies and associated with worse prognosis in most of these tumors, including …