CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Bacharelado em Física from Universidade de São Paulo (1993), master's at Physics from Universidade de São Paulo (1998) and doctorate at Physics from Universidade de São Paulo (2006). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: crio-microscopia eletrônica, microscopia eletrônica, análise de partículas isoladas, biologia molecular estrutural and análise de partícula única. (Source: Lattes Curriculum)
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Cryogenic electron microscopy (cryoEM) has undergone a revolution over the last years, allowing us to obtain high-resolution protein structures using minimal amounts of sample. The evolution that cryoEM experienced in recent years has been marked by several developments including microscopes, detectors, energy filters, sample preparation, as well as in data processing. However, acquiring …
Cooperation between Bioimaging and Structural Biology Research Infrastructures (RIs) has been strengthened in recent years, especially in the context of the EU-LAC ResInfra project. However, for these interactions to have an impact in Health, concrete global actions should be strategically planned, ensuring long-term sustainability. We are here proposing a coordinated biregional effort in…
Biological molecules in solution are the basis of life. Vitrified solutions of biological complexes can now be imaged directly in a cryogenic electron microscope (cryo-EM), and provide a window into the functioning of our bio-molecular machinery. However, the molecules only tolerate a very low electron exposure dose and the raw data are thus necessarily very noisy. Huge data sets (~Terab…
The Transmission Electron Microscope (TEM) has, since its invention in the 1930s, played a pivotal role in visualizing the processes of life. Many specimen preparation techniques have been developed for imaging biological samples including Cryogenic Electron Microscopy ("cryo-EM") which is typically aimed at elucidating the structure of vitreous-ice embedded macromolecular complexes. The …
This project aims at establishing a time-resolved cryo-EM methodology pipeline, which will include the testing and optimization of a previously developed hardware, together with data processing. This pipeline will allow to investigate macromolecular structural intermediates formed during reactions. Different biological macromolecules will be investigated, using the time-resolved approach,…
Single-particle cryo-EM has achieved a resolution level that can be used in drug discovery. This approach is of paramount importance for understanding the mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The Spike (S) protein, the surface glycoprotein involved in receptor recognition, viral attachment, and entry into host cells, is a key target for vaccine a…
| 3 / 3 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 8 | All research grants and scholarships |
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