Abstract
The arginase enzyme is the first enzyme in the polyamine synthesis pathway in Leishmania. It converts L-arginine into L-ornithine and urea. The ornithine decarboxylase (ODC) produces putrescine by L-ornithine decarboxylation. The putrescine is used as a substrate in the polyamines biosynthesis such as spermidine and spermine. Spermidine is a substrate of the trypanothione synthase that co…