Abstract
Bisphosphonates (BPs) are a class of drugs used in the treatment of some bone diseases or osteotropic malignancies. BPs exerts a potent inhibitory effect on bone resorption. Among the adverse effects is the occurrence of bisphosphonate-related osteonecrosis of the jaws (BRONJ). The risk factors for the onset of BRONJ are chronic use of nitrogen-containing- BPs, especially zoledronate, int…