CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Assistant Professor in the Department of Biochemistry at the University of São Paulo. BSc in Biomedicine from the Federal University of Rio de Janeiro, MSc in Molecular Biology from the Federal University of São Paulo, and PhD in Biochemistry from the Federal University of Rio de Janeiro. Completed postdoctoral training at the MRC Laboratory of Molecular Biology (as a Marie Curie Individual Fellow) and at University College London. Grantee Serrapilheira 2024. Areas of study: Proteostasis and the Biology of Aging. (Source: Lattes Curriculum)
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I will use protein aggregation sensors, genetics, and targeted lipid analysis in C. elegans and mice to test whether non-canonical signals (such as changes in lipid metabolism), rather than misfolded proteins alone, can trigger endoplasmic reticulum stress responses in distant tissues. This will help determine whether alternative, non-classical mechanisms drive cell-to-cell stress communi…
The ability to perceive the environment is an essential skill for the survival of organisms. In animals, these signals are sensed and transmitted through the nervous system. The endoplasmic reticulum plays a central role in the protein secretion and is a key component in stress responses. Thus, it is not surprising that the Unfolded Protein Response of the endoplasmic reticulum (UPRER) is…
An organism must be capable of perceiving environmental threats to maximize its chances of survival and the perpetuation of its species. In animals, the central nervous system receives and interprets these environmental signals. Inside cells, the Endoplasmic Reticulum (ER) plays a role in protein secretion pathways and is thus a key player in various stress response contexts. It has been …
Population aging is a major economic and healthcare challenge in the 21st century, with a projected 1.6 billion people over the age of 65 by 2050. In Brazil, 40% of the population is expected to be elderly in the coming decades. In this context, it is crucial to develop public policies and promote research focused on the health and quality of life of the elderly. Aging results from the ac…
The cell non-autonomous regulation of the proteostasis in peripheral tissue by neurons in animals has been known for at least a decade. However, only recently it was observed that glial cells can also promote this type of regulation. In Caenorhabditis elegans, the activation of stress pathways (UPRER/XBP-1, UPRMT/JMJD-1.2 and HSR/HSF-1) in CEPsh astrocyte-like glial cells can extend lifes…
Aging increases the risk of chronic diseases, being slowed by caloric restriction. Our group and coworkers identified that, in a conserved way, the synthesis of microRNAs decrease with aging, being reverted by caloric restriction. This phenomenon is a consequence of the regulation of the expression of key enzymes of the microRNA processing pathway, particularly Dicer, which cleaves pre-mi…
The central nervous system (CNS) coordinates a myriad of physiological functions in the body. Besides receiving signals from the environment to respond to infection, the CNS is also involved in the regulation of the immune system. In the CNS, glial cells can be as important as neurons, but the interaction between glia and the peripheral immune system in the model organism Caenorhabditis e…
C. elegans is a widely used model for aging studies due to its short lifespan and conserved genes that can be easily silenced by feeding worms with bacteria that express target-specific double stranded RNA (dsRNA). Worms carrying a loss-of-function mutation in the glp-1 gene do not develop the germline and therefore are long-lived - a phenomenon directly linked to increased nuclear locali…
| 2 / 2 | Ongoing grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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