Abstract
Neglected tropical diseases (NTDs) affect more than a billion people worldwide. Despite that few effective drugs are available to treat these diseases, especially those caused by trypanosomatides, such as Chagas disease (Trypanosoma cruzi) and leishmaniose (Leishmania spp.). The flavoenzyme dihydroorotate dehydrogenase (DHODH) is a potential molecular target for antiprotozoal substances s…