Abstract
The Excess Dietary Adenine (ADE) intratubular promotes precipitation of crystals, leading to a progressive installation of interstitial nephritis and renal function loss. Recent observations indicate that the overhead of ADE in mice in which genes for TLR-2, -4, MyD88, ASC or caspase-1 have been inactivated causes less damage to the kidney compared to administered to wild type mice, sugge…