CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
I'm a medical physicist with master degree in neurosciences and PhD in neuroimaging, both, by University of Campinas. I have experience in image analysis with emphasis in structural neuroimaging and statistical analysis. I performed researchs internship at the Radiology Department of Johns Hopkins University and Department of Electrical Engineering of Polytechnique Montreal. (Source: Lattes Curriculum)
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This project aims to develop advanced computational tools for the in vivo analysis of dorsal root ganglia (DRG) and spinal cord integrity, focusing on sensory neuronopathy. Dorsal root ganglia are essential for transmitting sensory information from the periphery to the central nervous system; however, their morphological and functional characteristics remain underexplored, particularly in…
Spinocerebellar ataxias (SCA) are a group of diseases that share cerebellar ataxia as a common clinical finding, but non-motor symptoms and cognitive deficits may also be present. Pathologically, SCA are characterized by severe neuronal loss in the cerebellum and brainstem, particularly in the dorsal root ganglia (DRG). Although these structures are highly relevant, there are still no mag…
Hereditary ataxias are a group of diseases that share cerebellar ataxia as a common clinical feature; however, non-motor symptoms and cognitive deficits may also be present. Pathologically, they are characterized by severe neuronal loss in the cerebellum and brainstem, particularly in the dorsal root ganglia. Despite the importance of these structures, there are currently no magnetic reso…
Hereditary ataxias (SCA) are a group of diseases that share cerebellar ataxia as a common clinical finding; however, non-motor symptoms and cognitive deficits may also be present. Pathologically, SCAs are characterized by severe neuronal loss in the cerebellum and brainstem, especially in the dentate nuclei of the cerebellum. Unfortunately, there are few imaging studies that aim to assess…
(Only some records are available in English at this moment)
It is possible to obtain anatomical images through the magnetic resonance technique, which allows us to evaluate the central nervous system, without prejudice to the individual. Thus, there are several studies that use this technique to evaluate brain damage in neurological diseases. Among these diseases, some are known for their phenotypic heterogeneity, which may lead to different patte…
Studies of reproducibility are one of the cornerstones of science and its lack reduces the scientific efforts done up to now. Neuroimaging studies are particularly sensitive to that, because the nature of the measures is complex and there is many segmentation methods with your own techniques. Specifically to the cerebellum, these are important issues, once that structure is tiny and highl…
Brain iron accumulation plays a key role in several neurodegenerative disorders, such as Parkinson's disease, Multiple Sclerosis and Friedreich ataxia. In this scenario, methods that enable in vivo identification and quantification of such deposits are extremely helpful in neurological practice. There are different MRI-based strategies to estimate iron deposition. T2*/T2 relaxometry is th…
Inherited cerebellar ataxias (ICA) represent a heterogeneous group of neurodegenerative disorders that share cerebellar ataxia as the core clinical finding. Pathologically, this group of diseases is characterized by severe neuronal loss in the cerebellum and brainstem. Cervical spinal cord atrophy is a hallmark of these disorders. This is indeed confirmed by quantitative neuroimaging data…
Voxel-based analyses of MRI datasets are widely used for quantitative analyses in neuroscience. This technique, unfortunately, has poor statistical power and high noise level leading to a low sensitivity for detection of abnormalities. In contrast, ROI-based analyses attenuate these shortcomings by grouping the voxels corresponding to the same anatomical structure, reducing, thereby, the …