Abstract
Histone modifications, such as methylation, acetylation and phosphorylation, play a pivotal role on epigenetic control of gene expression. Among such modifications, histone methylation is reversibly regulated by histone methyltransferases and demethylases. Lysine-Specific Demethylase 1 (LSD1), the first identified histone demethylase, is part of a large family of amino oxidases and cataly…