Abstract
Glioblastoma Multiforme (GBM) is the most aggressive and undifferentiated tumor type that affects the Central Nervous System (CNS). In chemotherapy, the antitumoral Temozolomide (TMZ) demonstrates the best clinical benefits by easily penetrating the blood-brain barrier. TMZ promotes DNA damage by adding methyl radicals (-CH3) in nitrogenous bases, which can cause nucleotide substitutions,…