Abstract
Chronic lymphocytic leukemia (CLL) is an age-associated malignancy characterized by the expansion of CD5+ B-1 cells. The NZB mouse model of CLL, which similar to human CLL, have an age-associated increase in malignant B-1 clones and decreased expression of miR-15a/16. A systemic lentiviral delivery of miR-15a/16 ameliorate disease manifestations of CLL in this mouse model, and also decrea…