Abstract
Chronic Lymphocytic leukemia (CLL) is characterized by a clonal accumulation of mature neoplastic B cells that are resistant to apoptosis. Ikaros is considered an important regulator of lymphoid development and differentiation. Several reports reinforce the hypothesis that Ikaros expression is deregulated in human leukemias. Patients with CLL can be categorized in 2 subsets on the basis o…