CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's at Medicina from Universidade Federal de Minas Gerais (1988), master's at Ciências Biológicas e Médicas from Université de Paris VII (1996) and doctorate at Medicina e Ciências from Université de Paris VII (2001). Has experience in Medicine, focusing on Hematology, acting on the following subjects: chronic myeloid leukaemia, bone marrow transplant, allogeneic bone marrow transplant, glanzmann's thrombasthenia and cd34 cell dose. (Source: Lattes Curriculum)
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The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
Recently, there has been a rapid expansion in the development of oncology therapeutics products. With significant commercial potential, cell and gene therapies have emerged as a promising advancement in the healthcare area. Immunotherapy with CAR-T cells has shown promising results in the treatment of refractory hematological malignancies. However, the successful application of CAR-T ther…
Recent studies and accomplishments on monogenic diseases have served not only to alleviate the dilemma of patients with these disorders, but also have yielded valuable information on biological processes relevant to other more common conditions. However, few centers are prepared to diagnose, follow up, and investigate monogenic developmental diseases in Brazil, the largest Latin American …
Multiple myeloma (MM) is a B cell neoplasia that accounts for 10% of all hematological tumors. Despite the progress in MM therapies most patients still relapse. CAR-T cell therapy with anti-BCMA (a receptor expressed exclusively by mature B and MM cells), are able to increase patient survival and delay relapses. Although there are some approved CAR-T therapy in agencies such as the FDA, a…
Cellular senescence is a physiological process associated with aging which is mainly characterized by the arrest of the cell cycle, metabolic and functional alterations and the acquisition of a pro-inflammatory secretory phenotype. However, stressors both internal and external to the cell can induce premature cellular senescence. Premature T-cell senescence has already been described in a…
The feasibility of gene therapy for sickle cell anemia (SCA) represents a curative treatment alternative for patients who are candidates for hematopoietic cell transplantation (HCT) but do not have an HLA-matched donor. This therapeutic modality is based on the genetic editing of autologous hematopoietic stem cells and progenitor cells. The main strategies employed include the addition of…
Immunotherapy has revolutionized cancer treatment in recent years, particularly adoptive cell therapy using chimeric antigen receptor (CAR) T cells for hematological tumors. However, for solid tumors, there are several ongoing preclinical and clinical studies showing a challenging scenario due to the lack of expansion and persistence of CAR T cells in vivo, difficulty in migration within …
| 2 / 2 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 8 / 8 | All research grants and scholarships |
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