I have a Pharmacy Degree (Pharm.D., 2002) and a Master Degree (M.Sc., 2004) in Pharmaceutical Sciences from Federal University of Pernambuco (Brazil), and a Doctoral Degree (Ph.D., 2009) from Federal University of São Paulo (Brazil). I was a post-doctoral associate at The Laboratories for Reproductive Biology, University of North Carolina - Chapel Hill (USA) from 2010 to 2012, and a Young Investigator - CNPq Program Science without Borders at the Department of Pharmacology, Universidade Federal de São Paulo from 2012 to 2015. Currently, I am an Assistant-Professor of Pharmacology at the ?Instituto de Biociências de Botucatu - Universidade Estadual Paulista Júlio de Mesquita Filho (IBB-Unesp)? I have experience in Pharmacology, focusing in Pharmacology Molecular Biochemistry, Experimental Endocrinology and Reproductive Biology, working on the following research fields: 1) Epididymis: characterization of mechanisms involved on the regulation of epididymal gene expression and functions, as well as identification of epididymal protein targets for the development of male contraceptive drugs; 2) Actions of androgen and glucocorticoid hormones in the male reproductive tract; 3) Functions and mechanism of action of antimicrobial genes as members of innate immunity in the male reproductive tract and their role in male fertility; and 4) Characterization of protein-protein interactions in the epididymis and sperm with roles in sperm maturation and motility. (Source: Lattes Curriculum)
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The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
Almost 30% of couples rely on the two currently available options of male contraception: condoms and vasectomy, which have issues regarding effectiveness and reversibility, respectively. Thus, there is an unmet need for new male contraceptive methods, which will contribute to decreasing unintended pregnancy rates and to improve family planning, health and well-being. Protein-protein inter…
Nearly 50% of the pregnancies worldwide are unintended, which causes 80,000 maternal deaths every year due to unsafe abortions. This indicates there is an unmet need for new male contraceptive methods, which would facilitate family planning and promote family health. EPPIN (Epididymal protease inhibitor) is a promising target for male contraception due to its crucial role on reproduction …
Novel male contraceptive strategies will foster the participation of men in family planning and sharing the contraceptive burden with women. The sperm protein EPPIN (epididymal protease inhibitor) is a target for non-hormonal, on-demand male contraceptive drug development. The physiological relevance of EPPIN is driven by its role as a sperm-surface binding site for seminal plasma protein…
Mammalian spermatozoa require a last maturation step in the female reproductive tract to fertilize the egg. This remarkable physiological process, known as capacitation, prepares spermatozoa to undergo acrosome reaction (AR). At the molecular level, activation of the adenylyl cyclase/cyclic AMP/protein kinase A (AC/cAMP/PKA) pathway and phosphorylation cascades and hyperpolarization of th…
EPPIN (Epididymal protease inhibitor) is a sperm surface protein recognized as a target for the development of male contraceptive drugs, due to its critical role on sperm function. EPPIN is expressed in the testis and epididymis, and is found on the human sperm surface, where it inhibits sperm motility after ejaculation via interaction with the seminal plasma protein SEMG1 (semenogelin-1)…
In mammals, proteins belonging to the REST (rapidly-evolving seminal vesicle transcribed) family, secreted by the seminal vesicles, are the most abundant components of the seminal plasma. In humans, the major REST protein is semenogelin-1 (SEMG1), which binds EPPIN on the surface of ejaculated spermatozoa, leading to inhibition of sperm motility that lasts until SEMG1 is cleaved by prosta…
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After ejaculation, mammalian spermatozoa need to undergo several molecular and biochemistry changes to fertilize the egg. The major protein of the seminal plasma is semenogelin 1 (SEMG1), which plays several roles in the modulation of sperm function, such as motility, hyperactivation and capacitation. SEMG1 modulates sperm function by interacting with EPPIN, a cysteine-rich protein found …
| 2 / 2 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 18 / 16 | All research grants and scholarships |
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