CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Challenge and a continuous drive to learn motivate my commitment to scientific advancement.I hold a Bachelors degree in Pharmacy from the Federal University of Pernambuco (UFPE, 2002), a Masters degree in Pharmaceutical Sciences from UFPE (2004), and a Ph.D. in Pharmacology from the Federal University of São Paulo Escola Paulista de Medicina (Unifesp-EPM, 2009). I earned my Habilitation (Livre-Docência) in Pharmacology from São Paulo State University (UNESP, 2025). I completed postdoctoral training at the University of North Carolina at Chapel Hill, USA (20102012). I was a recipient of a Young Talent Fellowship (BJT) from the Science Without Borders Program (Young Talent Attraction modality) at the Experimental Endocrinology Sector, Department of Pharmacology, Unifesp-EPM (20122015). Since 2014, I have been a faculty member of the Department of Biophysics and Pharmacology at the Institute of Biosciences of Botucatu, São Paulo State University (UNESP), where I currently serve as Associate Professor. I have solid international research experience, with an emphasis on Molecular Pharmacology, Experimental Endocrinology, Reproductive Biology, and Andrology. My academic and scientific activities focus on investigating the molecular and cellular mechanisms that regulate male reproductive tract function, with particular emphasis on: (i) the study of epididymal function, including molecular and cellular regulatory mechanisms involved in gene expression control, as well as the pathophysiological mechanisms underlying epididymal inflammatory responses (epididymitis); (ii) the functional characterization of epididymal and sperm targets essential for sperm maturation, motility, and capacitation, with a focus on identifying pharmacological targets for the development of non-hormonal male contraceptives; (iii) the actions of androgenic and glucocorticoid hormones in the male reproductive tract; and (iv) the role of antimicrobial genes as components of innate immunity in the male reproductive tract and their impact on fertility. (Source: Lattes Curriculum)
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A Rede de Biotérios do Instituto de Biociências de Botucatu, Universidade Estadual Paulista (IBB/UNESP) compreende nove unidades especializadas em manutenção e experimentação animal, localizadas em diferentes edifícios do instituto. Os biotérios da Rede atendem integralmente às demandas dos grupos de pesquisa liderados por docentes do IBB/UNESP e seus colaboradores internos ou externos, c…
The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
Almost 30% of couples rely on the two currently available options of male contraception: condoms and vasectomy, which have issues regarding effectiveness and reversibility, respectively. Thus, there is an unmet need for new male contraceptive methods, which will contribute to decreasing unintended pregnancy rates and to improve family planning, health and well-being. Protein-protein inter…
Whey-acidic protein four-disulfide core domain (WFDC) genes display putative roles in innateimmunity and fertility. In mice, a locus on chromosome 2 contains 5 and 11 Wfdc genes in itscentromeric and telomeric subloci, respectively. Although Wfdc genes are highly expressed inthe epididymis, their contributions to epididymal function remain elusive. Here, we investigatedwhether Wfdc genes …
Nearly 50% of the pregnancies worldwide are unintended, which causes 80,000 maternal deaths every year due to unsafe abortions. This indicates there is an unmet need for new male contraceptive methods, which would facilitate family planning and promote family health. EPPIN (Epididymal protease inhibitor) is a promising target for male contraception due to its crucial role on reproduction …
Dengue virus (DENV) is one of the flaviviruses with the greatest impact on global public health, with four distinct serotypes and widespread distribution in tropical and subtropical regions. In 2024, Brazil recorded the largest dengue epidemic in its history. The disease can be asymptomatic or induce symptoms ranging from fever, chills, headache, and myalgia to hemorrhagic manifestations …
Upon release from the seminiferous tubules, spermatozoa undergo essential post-testicular maturation in the epididymis to acquire full motility and fertilization capacity. The epididymis, a single, highly coiled, and convoluted tubule, hosts spermatozoa in a luminal compartment surrounded by a pseudostratified epithelium composed of various cell types. The interaction between immune cells…
(Only some records are available in English at this moment)
Novel male contraceptive strategies will foster the participation of men in family planning and sharing the contraceptive burden with women. The sperm protein EPPIN (epididymal protease inhibitor) is a target for non-hormonal, on-demand male contraceptive drug development. The physiological relevance of EPPIN is driven by its role as a sperm-surface binding site for seminal plasma protein…
In mammals, proteins belonging to the REST (rapidly-evolving seminal vesicle transcribed) family, secreted by the seminal vesicles, are the most abundant components of the seminal plasma. In humans, the major REST protein is semenogelin-1 (SEMG1), which binds EPPIN on the surface of ejaculated spermatozoa, leading to inhibition of sperm motility that lasts until SEMG1 is cleaved by prosta…
(Only some records are available in English at this moment)
Post-testicular sperm maturation occurs in the epididymis, a highly specialized duct essential for the acquisition of motility, fertilizing ability, and long-term storage of spermatozoa. Epididymitis, most commonly caused by ascending bacterial infections, is a prevalent male urogenital disorder that induces epithelial and smooth muscle cell injury, particularly in distal regions, thereby…
The sperm proteome contains exclusively expressed proteins with essential roles in male fertility, which may have therapeutic applications in male contraception. Among the proteins that fit into this profile, we highlight the protein phosphatase 1 gamma 2 (PP1¿2). PP1¿2 is a sperm-specific isoform of a family of phosphatases that act dephosphorylating serine/threonine residues of target p…
After ejaculation, mammalian spermatozoa need to undergo several molecular and biochemistry changes to fertilize the egg. The major protein of the seminal plasma is semenogelin 1 (SEMG1), which plays several roles in the modulation of sperm function, such as motility, hyperactivation and capacitation. SEMG1 modulates sperm function by interacting with EPPIN, a cysteine-rich protein found …